FOG01784
EOG87H456

sce:NTH1;NTH2

Genes: 35

SGD Description
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication|Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication


PomBase Description
alpha,alpha-trehalase Ntp1


AspGD Description
Trehalase; responsible for degradation of intracellular trehalose; mutant conidiophores produce fewer and less viable spores; highly expressed in dormant conidia


References

Mann C, et al. (1986 Jan). Structure and sequence of the centromeric DNA of chromosome 4 in Saccharomyces cerevisiae.

App H, et al. (1989 Oct 15). Purification and characterization of neutral trehalase from the yeast ABYS1 mutant.

Kopp M, et al. (1993 Mar 5). Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae.

Kopp M, et al. (1994 Dec 15). Corrected sequence of the yeast neutral trehalase-encoding gene (NTH1): biological implications.

Nwaka S, et al. (1995 Apr 28). Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae.

Amaral FC, et al. (1997 Apr). Molecular cloning of the neutral trehalase gene from Kluyveromyces lactis and the distinction between neutral and acid trehalases.

d'Enfert C, et al. (1999 May). Neutral trehalases catalyse intracellular trehalose breakdown in the filamentous fungi Aspergillus nidulans and Neurospora crassa.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Ni M, et al. (2007 Oct 3). A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Svanström A, et al. (2013 Feb-Mar). Intracellular trehalase activity is required for development, germination and heat-stress resistance of Aspergillus niger conidia.

Krijgsheld P, et al. (2013 Mar 15). Development in Aspergillus.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%