FOG01780
EOG81VHHX

sce:TPS1

Genes: 34

SGD Description
Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid


PomBase Description
alpha,alpha-trehalose-phosphate synthase


AspGD Description
Putative alpha, alpha-trehalose-phosphate synthase; several copies of C4T stress-responsive element in 5' region; transcription induced by heat shock; appears not to be involved in glucose sensing|Alpha,alpha-trehalose phosphate synthase (UDP-forming); transcription is constitutive and is enhanced on carbon-derepressing carbon sources; appears not to be involved in glucose sensing; highly expressed in dormant conidia


References

Nelson H, et al. (1989 Jan 25). A conserved gene encoding the 57-kDa subunit of the yeast vacuolar H+-ATPase.

Vandercammen A, et al. (1989 Jul 1). Characterization of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase of Saccharomyces cerevisiae.

González MI, et al. (1992 Mar). Molecular cloning of CIF1, a yeast gene necessary for growth on glucose.

Bell W, et al. (1992 Nov 1). Characterization of the 56-kDa subunit of yeast trehalose-6-phosphate synthase and cloning of its gene reveal its identity with the product of CIF1, a regulator of carbon catabolite inactivation.

McDougall J, et al. (1993 Feb 15). A yeast gene for trehalose-6-phosphate synthase and its complementation of an Escherichia coli otsA mutant.

Van Aelst L, et al. (1993 May). Molecular cloning of a gene involved in glucose sensing in the yeast Saccharomyces cerevisiae.

Luyten K, et al. (1993 Oct 15). Disruption of the Kluyveromyces lactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake.

Londesborough J, et al. (1993 Sep 15). Purification of trehalose synthase from baker's yeast. Its temperature-dependent activation by fructose 6-phosphate and inhibition by phosphate.

Vuorio OE, et al. (1993 Sep 15). Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae.

Cannon JF, et al. (1994 Feb). Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae.

Blázquez MA, et al. (1994 Jul). Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe.

Degols G, et al. (1996 Jun). Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Ribeiro MJ, et al. (1997 Aug). Trehalose synthesis is important for the acquisition of thermotolerance in Schizosaccharomyces pombe.

Reinders A, et al. (1997 May). Structural analysis of the subunits of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock.

Zaragoza O, et al. (1998 Aug). Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity.

Cansado J, et al. (1998 Aug 24). Trehalose-6P synthase is essential for trehalase activation triggered by glucose, nitrogen source or heat shock, but not by osmostress, in Schizosaccharomyces pombe.

Bell W, et al. (1998 Dec 11). Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.

Cansado J, et al. (1998 Mar). Characterization of mutants devoid of neutral trehalase activity in the fission yeast Schizosaccharomyces pombe: partial protection from heat shock and high-salt stress.

Soto T, et al. (1999 May). Accumulation of trehalose by overexpression of tps1, coding for trehalose-6-phosphate synthase, causes increased resistance to multiple stresses in the fission yeast schizosaccharomyces pombe

Dong ZY, et al. (2000 May). [cDNA cloning, sequence analysis of trehalose-6-phosphate synthase gene from Saccharomyces cerevisiae AS2.1416].

Fillinger S, et al. (2001 Jul). Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans.

Soto T, et al. (2002 Aug). Molecular interaction of neutral trehalase with other enzymes of trehalose metabolism in the fission yeast Schizosaccharomyces pombe.

Soto T, et al. (2002 Oct). Cold induces stress-activated protein kinase-mediated response in the fission yeast Schizosaccharomyces pombe.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Paredes V, et al. (2003 Jul). Different roles for the stress-activated protein kinase pathway in the regulation of trehalose metabolism in Schizosaccharomyces pombe.

Franco A, et al. (2005 Sep). Functional characterization of Schizosaccharomyces pombe neutral trehalase altered in phosphorylatable serine residues.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Ni M, et al. (2007 Oct 3). A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Park HS, et al. (2012 Dec). Genetic control of asexual sporulation in filamentous fungi.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.

Krijgsheld P, et al. (2013 Mar 15). Development in Aspergillus.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01781
EOG81VHHX

sce:TPS3;TSL1

Genes: 34

SGD Description
Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication|Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication


PomBase Description
alpha,alpha-trehalose-phosphate synthase (predicted)


AspGD Description
Putative alpha,alpha-trehalose phosphate synthase; highly expressed in dormant conidia|Predicted alpha,alpha-trehalose-phosphate synthase


References

Vuorio OE, et al. (1993 Sep 15). Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae.

Reinders A, et al. (1997 May). Structural analysis of the subunits of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock.

Bell W, et al. (1998 Dec 11). Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG01782
EOG81VHHX

sce:TPS2

Genes: 34

SGD Description
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress


PomBase Description
trehalose-6-phosphate phosphatase Tpp1|trehalose-phosphate synthase Tps2 (predicted)


AspGD Description
Trehalose phosphatase


References

Vandercammen A, et al. (1989 Jul 1). Characterization of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase of Saccharomyces cerevisiae.

Ronne H, et al. (1991 Oct). Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis.

Borgia PT, et al. (1992 Jan). Roles of the orlA, tsE, and bimG genes of Aspergillus nidulans in chitin synthesis.

De Virgilio C, et al. (1993 Mar 1). Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity.

Borgia PT, et al. (1996 Jun). The orlA gene from Aspergillus nidulans encodes a trehalose-6-phosphate phosphatase necessary for normal growth and chitin synthesis at elevated temperatures.

Reinders A, et al. (1997 May). Structural analysis of the subunits of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock.

Bell W, et al. (1998 Dec 11). Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Ni M, et al. (2007 Oct 3). A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01783
EOG81VHHX

sce:absent

Genes: 2

AspGD Description
Alpha,alpha-trehalosephosphate synthase (UDP-forming); highly expressed in dormant conidia

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%