FOG01595
EOG8THT9X

sce:THI4

Genes: 32

SGD Description
Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents


PomBase Description
thiazole biosynthetic enzyme


AspGD Description
Thiazole biosynthesis protein


References

KAFER E, et al. (1958). An 8-chromosome map of Aspergillus nidulans.

Käfer E, et al. (1965 Jul). Origins of translocations in Aspergillus nidulans.

Purnell DM, et al. (1973 Jul 31). The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Purnell DM, et al. (1978 Dec 18). Virulence genetics of Aspergillus nidulans Eidam: a review.

Praekelt UM, et al. (1992 Sep). MOL1, a Saccharomyces cerevisiae gene that is highly expressed in early stationary phase during growth on molasses.

Praekelt UM, et al. (1994 Apr). Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Machado CR, et al. (1997 Oct 17). Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Faou P, et al. (2004 Dec 3). Neurospora crassa CyPBP37: a cytosolic stress protein that is able to replace yeast Thi4p function in the synthesis of vitamin B1.

Medina-Silva R, et al. (2006 Apr). Heat stress promotes mitochondrial instability and oxidative responses in yeast deficient in thiazole biosynthesis.

Mojzita D, et al. (2006 Aug). Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae.

Chatterjee A, et al. (2006 Jun 7). Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis.

Jurgenson CT, et al. (2006 Sep 19). Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae.

Chatterjee A, et al. (2007 Mar 14). Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate.

Chatterjee A, et al. (2008 Aug 27). Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Chatterjee A, et al. (2011 Oct 26). Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.

Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%