FOG01596
EOG8QJQ3M

sce:THI20;THI21

Genes: 38

SGD Description
Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p|Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p


PomBase Description
phosphomethylpyrimidine kinase (predicted)


AspGD Description
Ortholog(s) have role in thiamine biosynthetic process and cytosol localization


References

Käfer E, et al. (1965 Jul). Origins of translocations in Aspergillus nidulans.

Purnell DM, et al. (1973 Jul 31). The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Llorente B, et al. (1999 Jun). Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway.

Schoustra S, et al. (2010 Aug 10). Fitness-associated sexual reproduction in a filamentous fungus.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG01597
EOG8QJQ3M

sce:THI22

Genes: 1

SGD Description
Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis


References

Llorente B, et al. (1999 Jun). Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01598
EOG8QJQ3M

sce:DBP1;DED1

Genes: 35

SGD Description
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication|ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase; required for translation initiation of all yeast mRNAs; binds to mRNA cap-associated factors, and binding stimulates Ded1p RNA-dependent ATPase activity; mutation in human homolog DBY is associated with male infertility; human homolog DDX3X complements ded1 null mutation; DED1 has a paralog, DBP1, that arose from the whole genome duplication


PomBase Description
translation initiation RNA helicase Sum3


AspGD Description
Ortholog(s) have mRNA binding, translation initiation factor activity, role in cytoplasmic translational initiation and cytosol localization


References

Struhl K, et al. (1985 Dec 9). Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region.

Chang TH, et al. (1990 Feb). Identification of five putative yeast RNA helicase genes.

Jamieson DJ, et al. (1991 Apr). A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase.

Jamieson DJ, et al. (1991 Feb 21). A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.

Thuillier V, et al. (1995 Jan 16). A mutation in the C31 subunit of Saccharomyces cerevisiae RNA polymerase III affects transcription initiation.

Chuang RY, et al. (1997 Mar 7). Requirement of the DEAD-Box protein ded1p for messenger RNA translation.

de la Cruz J, et al. (1997 May 13). The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae.

Iost I, et al. (1999 Jun 18). Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase.

Noueiry AO, et al. (2000 Nov 21). A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA.

Kushner DB, et al. (2003 Dec 23). Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus.

Chong JL, et al. (2004). Ded1p, a conserved DExD/H-box translation factor, can promote yeast L-A virus negative-strand RNA synthesis in vitro.

Berthelot K, et al. (2004 Feb). Dynamics and processivity of 40S ribosome scanning on mRNA in yeast.

Cordin O, et al. (2004 Jul 7). The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity.

Yang Q, et al. (2005 Oct 18). ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Banroques J, et al. (2008 May). A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Low JK, et al. (2013 Sep 6). Analysis of the proteome of Saccharomyces cerevisiae for methylarginine.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01599
EOG8QJQ3M

sce:DBP2

Genes: 33

SGD Description
ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; interacts with YRA1; required for the assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites


PomBase Description
ATP-dependent RNA helicase Dbp2


AspGD Description
Ortholog(s) have cytosol, nucleolus localization


References

Dequard-Chablat M, et al. (1991 Aug 15). RPC19, the gene for a subunit common to yeast RNA polymerases A (I) and C (III).

Iggo RD, et al. (1991 Mar). p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts.

He F, et al. (1995 Feb 15). Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

Bond AT, et al. (2001 Nov). Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.

Tallada VA, et al. (2002 Sep 30). Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Keller C, et al. (2010 Jun). Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Zhang K, et al. (2011 Mar 25). Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Drogat J, et al. (2012 Nov 29). Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Shchepachev V, et al. (2012 Oct 25). Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Jongjitwimol J, et al. (2014). The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Kilchert C, et al. (2015 Dec 22). Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01600
EOG8QJQ3M

sce:DBP3

Genes: 33

SGD Description
RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype


PomBase Description
ATP-dependent RNA helicase Dbp3 (predicted)


AspGD Description
Ortholog(s) have ATP-dependent RNA helicase activity and role in endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)


References

Chang TH, et al. (1990 Feb). Identification of five putative yeast RNA helicase genes.

Weaver PL, et al. (1997 Mar). Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG01601
EOG8QJQ3M

sce:PRP5

Genes: 32

SGD Description
RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA


PomBase Description
ATP-dependent RNA helicase Prp11


AspGD Description
Ortholog(s) have ATPase activity, U1 snRNP binding, U2 snRNP binding activity, role in U2-type prespliceosome assembly and U2-type prespliceosome, cytosol, mitotic spindle pole body localization


References

Dalbadie-McFarland G, et al. (1990 Jun). PRP5: a helicase-like protein required for mRNA splicing in yeast.

Ruby SW, et al. (1993 Oct). Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA.

Wells SE, et al. (1994 Sep). Interactions between highly conserved U2 small nuclear RNA structures and Prp5p, Prp9p, Prp11p, and Prp21p proteins are required to ensure integrity of the U2 small nuclear ribonucleoprotein in Saccharomyces cerevisiae.

O'Day CL, et al. (1996 Dec 27). The Saccharomyces cerevisiae Prp5 protein has RNA-dependent ATPase activity with specificity for U2 small nuclear RNA.

Wiest DK, et al. (1996 Dec 27). In vitro studies of the Prp9.Prp11.Prp21 complex indicate a pathway for U2 small nuclear ribonucleoprotein activation.

Yan D, et al. (1996 Mar). Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.

Abu Dayyeh BK, et al. (2002 Jun 7). Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5.

Perriman R, et al. (2003 Nov 25). ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA.

Wang Q, et al. (2005 Dec). Interactions of the yeast SF3b splicing factor.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01602
EOG8QJQ3M

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted ATP binding, ATP-dependent helicase activity, helicase activity, nucleic acid binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01603
EOG8QJQ3M

sce:absent

Genes: 2

PomBase Description
phosphomethylpyrimidine kinase (predicted)


References

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%