FOG01519
EOG8JDFNV

sce:RNR1;RNR3

Genes: 35

SGD Description
Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication|Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication


PomBase Description
ribonucleoside reductase large subunit Cdc22


AspGD Description
Ribonucleotide reductase


References

Elledge SJ, et al. (1990 May). Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.

Yagle K, et al. (1990 Oct). The DNA damage-inducible gene DIN1 of Saccharomyces cerevisiae encodes a regulatory subunit of ribonucleotide reductase and is identical to RNR3.

Ozier-Kalogeropoulos O, et al. (1994 Feb). Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae.

Chabes A, et al. (1999 Dec 17). Yeast Sml1, a protein inhibitor of ribonucleotide reductase.

Chabes A, et al. (2000 Mar 14). Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.

Domkin V, et al. (2002 May 24). Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.

Yao R, et al. (2003 May 27). Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.

Xu H, et al. (2006 Mar 14). Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.

Xu H, et al. (2006 Mar 14). Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation.

Xu H, et al. (2008 Aug 14). The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01520
EOG8JDFNV

sce:absent

Genes: 21

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%