FOG01521
EOG851C7M

sce:RNR2

Genes: 35

SGD Description
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication


PomBase Description
ribonucleotide reductase small subunit Suc22


AspGD Description
Ribonucleotide reductase


References

Elledge SJ, et al. (1987 Aug). Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.

Hurd HK, et al. (1987 Oct). Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.

Fernandez Sarabia MJ, et al. (1993 Apr). The cell cycle genes cdc22+ and suc22+ of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase.

Harris P, et al. (1996 Sep 13). Cell cycle, DNA damage and heat shock regulate suc22+ expression in fission yeast.

Wang SW, et al. (1999 Mar). Caffeine can override the S-M checkpoint in fission yeast.

Nguyen HH, et al. (1999 Oct 26). Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly.

Chabes A, et al. (2000 Mar 14). Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.

Voegtli WC, et al. (2001 Aug 28). Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer.

Saitoh S, et al. (2002 May 31). Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Yoshida SH, et al. (2003 Jul). The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.

Liu C, et al. (2003 May 1). Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms.

Yao R, et al. (2003 May 27). Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.

Sommerhalter M, et al. (2004 Jun 22). Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Lima JF, et al. (2005 Nov). The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response.

Liu C, et al. (2005 Nov 16). Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.

Håkansson P, et al. (2006 Jan 20). The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit.

Takahashi S, et al. (2007). Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Lee YD, et al. (2008 Oct 10). Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Vejrup-Hansen R, et al. (2014 Jun 1). Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.

Xu YJ, et al. (2016 Apr). Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 35 genes with posterior transmembrane prediction > 50%

FOG01522
EOG851C7M

sce:RNR4

Genes: 3

SGD Description
Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication


References

Wang PJ, et al. (1997 Oct). Rnr4p, a novel ribonucleotide reductase small-subunit protein.

Nguyen HH, et al. (1999 Oct 26). Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly.

Chabes A, et al. (2000 Mar 14). Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.

Voegtli WC, et al. (2001 Aug 28). Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer.

Yao R, et al. (2003 May 27). Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.

Sommerhalter M, et al. (2004 Jun 22). Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Lee YD, et al. (2008 Oct 10). Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%