FOG01513
EOG81ZCXV

sce:ADK1

Genes: 33

Protein description
Mitochondrial and cytoplasmic adenylate kinase


Features
[m];[c]


SGD Description
Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress


PomBase Description
adenylate kinase Adk1


AspGD Description
Adenylate kinase


References

Tomasselli AG, et al. (1986 Feb 17). The complete amino acid sequence of adenylate kinase from baker's yeast.

Magdolen V, et al. (1987). The complete nucleotide sequence of the gene coding for yeast adenylate kinase.

Proba K, et al. (1987 Sep 11). The cDNA sequence encoding cytosolic adenylate kinase from baker's yeast (Saccharomyces cerevisiae).

Bandlow W, et al. (1988 Dec 15). Yeast adenylate kinase is active simultaneously in mitochondria and cytoplasm and is required for non-fermentative growth.

Konrad M, et al. (1988 Dec 25). Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae.

Hoang VQ, et al. (1991 Mar 1). Adenylate kinase isoenzymes in Aspergillus nidulans.

Davies CJ, et al. (1995 Feb 11). Insertion site specificity of the transposon Tn3.

Abele U, et al. (1995 Jul). High-resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer.

Spuergin P, et al. (1995 Jul 15). Stability, activity and structure of adenylate kinase mutants.

Schlauderer GJ, et al. (1996 Feb 23). Structure of a mutant adenylate kinase ligated with an ATP-analogue showing domain closure over ATP.

Schricker R, et al. (2002 Aug 9). Redundant mitochondrial targeting signals in yeast adenylate kinase.

Gauthier S, et al. (2008 Jun). Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01514
EOG81ZCXV

sce:absent

Genes: 32

Protein description
Mitochondrial? cytidylate kinase


Features
[m]?


AspGD Description
Cytidylate kinase


References

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%

FOG01515
EOG81ZCXV

sce:URA6

Genes: 1

Protein description
Uridylate kinase, enzyme predicted to be cytoplasmic unlike other orthologs


Features
[c]


Parent
ortholog:FOG01514


SGD Description
Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)


References

Liljelund P, et al. (1989 Nov 30). Primary structure of the S. cerevisiae gene encoding uridine monophosphokinase.

Choi WJ, et al. (1989 Sep 15). The Saccharomyces cerevisiae SOC8-1 gene and its relationship to a nucleotide kinase.

Ma JJ, et al. (1990 Nov 5). Purification and characterization of Saccharomyces cerevisiae uridine monophosphate kinase.

Jiang ZR, et al. (1991 Sep 25). Molecular characterization of Saccharomyces cerevisiae URA6 gene. DNA sequence, mutagenesis analysis, and cell cycle regulation relevant to its suppression mechanism to cdc8 mutation.

Schricker R, et al. (1992 Dec 1). The adenylate kinase family in yeast: identification of URA6 as a multicopy suppressor of deficiency in major AMP kinase.

Jong A, et al. (1993 Jul). Characteristics, substrate analysis, and intracellular location of Saccharomyces cerevisiae UMP kinase.

Müller-Dieckmann HJ, et al. (1994 Feb 11). The structure of uridylate kinase with its substrates, showing the transition state geometry.

Müller-Dieckmann HJ, et al. (1995 Mar 3). Substrate specificity and assembly of the catalytic center derived from two structures of ligated uridylate kinase.

Bao J, et al. (2006 Feb 20). Cloning of deoxynucleoside monophosphate kinase genes and biosynthesis of deoxynucleoside diphosphates.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01516
EOG81ZCXV

sce:absent

Genes: 1

Protein description
Uridylate kinase, enzyme predicted to be cytoplasmic unlike other orthologs


Features
[c]


Parent
ortholog:FOG01514


PomBase Description
uridylate kinase (predicted)


References

Vachon L, et al. (2013 Aug). Functional characterization of fission yeast transcription factors by overexpression analysis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01517
EOG81ZCXV

sce:ADK2

Genes: 33

Protein description
Mitochondrial adenylate kinase


Features
[m]


SGD Description
Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background


AspGD Description
Adenylate kinase


References

Hoang VQ, et al. (1991 Mar 1). Adenylate kinase isoenzymes in Aspergillus nidulans.

Schricker R, et al. (1992 Jun). A new member of the adenylate kinase family in yeast: PAK3 is highly homologous to mammalian AK3 and is targeted to mitochondria.

Cooper AJ, et al. (1992 May 1). A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae.

Schricker R, et al. (1995 Dec 29). Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae.

Gu Y, et al. (2005 May 13). A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01518
EOG81ZCXV

sce:absent

Genes: 2

Protein description
Uncharacterized paralog

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%