FOG01374
EOG8GTHWC

sce:CYS4

Genes: 26

SGD Description
Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria


AspGD Description
Cystathionine beta-synthase


References

Pieniazek NJ, et al. (1973 Nov 22). Deficiency in methionine adenosyltransferase resulting in limited repressibility of methionine biosynthetic enzymes in Aspergillus nidulans.

Paszewski A, et al. (1974). Regulation of S-amino acids biosynthesis in Aspergillus nidulans. Role of cysteine and-or homocysteine as regulatory effectors.

Pieniazek NJ, et al. (1974). An Aspergillus nidulans mutant lacking serine transacetylase: evidence for two pathways of cysteine biosynthesis.

Steień PP, et al. (1975). Cysteine biosynthesis in Aspergillus nidulans.

Paszewski A, et al. (1975 Nov). Enzymatic lesions in methionine mutants of Aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis.

Cherest H, et al. (1993 Sep). Cysteine biosynthesis in Saccharomyces cerevisiae occurs through the transsulfuration pathway which has been built up by enzyme recruitment.

Paszewski A, et al. (1994). Sulphur metabolism.

Kruger WD, et al. (1994 Jul 5). A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Marcos AT, et al. (2001 Feb). Characterization of the reverse transsulfuration gene mecB of Acremonium chrysogenum, which encodes a functional cystathionine-gamma-lyase.

Brzywczy J, et al. (2007 Jun). Multiple fungal enzymes possess cysteine synthase activity in vitro.

Sieńko M, et al. (2009 Oct). Aspergillus nidulans genes encoding reverse transsulfuration enzymes belong to homocysteine regulon.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%