FOG01375
EOG8KKWK1

sce:CYS3

Genes: 27

SGD Description
Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress


AspGD Description
Cystathionine gamma-lyase


References

Paszewski A, et al. (1973). Studies on beta-cystathionase and omicron-acetylhomoserine sulfhydrylase as the enzymes of alternative methionine biosynthetic pathways in Aspergillus nidulans.

Pieniazek NJ, et al. (1973 Nov 22). Deficiency in methionine adenosyltransferase resulting in limited repressibility of methionine biosynthetic enzymes in Aspergillus nidulans.

Paszewski A, et al. (1974). Regulation of S-amino acids biosynthesis in Aspergillus nidulans. Role of cysteine and-or homocysteine as regulatory effectors.

Steień PP, et al. (1975). Cysteine biosynthesis in Aspergillus nidulans.

Paszewski A, et al. (1975 Nov). Enzymatic lesions in methionine mutants of Aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis.

Ono B, et al. (1992 May). Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae.

Barton AB, et al. (1993 Apr). Physical localization of yeast CYS3, a gene whose product resembles the rat gamma-cystathionase and Escherichia coli cystathionine gamma-synthase enzymes.

Ono B, et al. (1993 Apr). Cystathionine gamma-lyase of Saccharomyces cerevisiae: structural gene and cystathionine gamma-synthase activity.

Yamagata S, et al. (1993 Aug). Cloning and bacterial expression of the CYS3 gene encoding cystathionine gamma-lyase of Saccharomyces cerevisiae and the physicochemical and enzymatic properties of the protein.

Paszewski A, et al. (1994). Sulphur metabolism.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Marcos AT, et al. (2001 Feb). Characterization of the reverse transsulfuration gene mecB of Acremonium chrysogenum, which encodes a functional cystathionine-gamma-lyase.

Messerschmidt A, et al. (2003 Mar). Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison.

Sieńko M, et al. (2009 Oct). Aspergillus nidulans genes encoding reverse transsulfuration enzymes belong to homocysteine regulon.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01376
EOG8KKWK1

sce:STR3

Genes: 32

SGD Description
Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation


PomBase Description
cystathionine beta-lyase (predicted)


AspGD Description
Cystathionine beta-lyase


References

Lilly LJ, et al. (1965 Apr). An investigation of the suitability of the suppressors of meth 1 in Aspergillus nidulans for the study of induced and spontaneous mutation.

Käfer E, et al. (1965 Jul). Origins of translocations in Aspergillus nidulans.

Putrament A, et al. (1970). Further genetic characteristics of methionine mutants and their suppressors in Aspergillus nidulans.

Purnell DM, et al. (1973 Jul 31). The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Paszewski A, et al. (1975 Nov). Enzymatic lesions in methionine mutants of Aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis.

Scott BR, et al. (1976 Jun). UV mutagenesis in inhibitor depleted conidia of Aspergillus nidulans.

Purnell DM, et al. (1978 Dec 18). Virulence genetics of Aspergillus nidulans Eidam: a review.

Bal J, et al. (1978 Feb 16). Supersuppressors in Aspergillus nidulans.

Bal J, et al. (1979 Dec). Allele specific and locus non-specific suppressors in Aspergillus nidulans.

Martinez-Rossi NM, et al. (1987 Jan). Detection of point-mutation mutagens in Aspergillus nidulans: comparison of methionine suppressors and arginine resistance induction by fungicides.

Hooley P, et al. (1988 Nov). An adaptive response to alkylating agents in Aspergillus nidulans.

Nadolska-Lutyk J, et al. (1989 Apr 15). Interrelated regulation of sulphur-containing amino-acid biosynthetic enzymes and folate-metabolizing enzymes in Aspergillus nidulans.

Paszewski A, et al. (1994). Sulphur metabolism.

de la Torre RA, et al. (1994 Mar 1). Genotoxic activity of mebendazole in Aspergillus nidulans.

Donnelly E, et al. (1994 Nov 28). Germinating conidiospores of Aspergillus amino acid auxotrophs are hypersensitive to heat shock, oxidative stress and DNA damage.

Donnelly E, et al. (1995 Dec 18). Quantification of DNA damage and repair in amino acid auxotrophs and UV-sensitive mutants of Aspergillus nidulans using an ELISA.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Sieńko M, et al. (1999 Jul). The metG gene of Aspergillus nidulans encoding cystathionine beta-lyase: cloning and analysis.

Hansen J, et al. (2000 Apr). Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae.

Bruggeman J, et al. (2004 Feb). Selection arena in Aspergillus nidulans.

Brzywczy J, et al. (2007 Jun). Multiple fungal enzymes possess cysteine synthase activity in vitro.

Brzywczy J, et al. (2011 Feb). Novel mutations reveal two important regions in Aspergillus nidulans transcriptional activator MetR.

Sugiyama T, et al. (2012). Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%