FOG01306
EOG89CNQ5

sce:HIS7

Genes: 32

SGD Description
Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor


PomBase Description
imidazoleglycerol-phosphate synthase (predicted)


AspGD Description
Glutamine amidotransferase:cyclase/imidazole glycerol phosphate synthase


References

Berlyn MB, et al. (1967 Nov). Gene-enzyme relationships in histidine biosynthesis in Aspergillus nidulans.

Kuenzler M, et al. (1993 Sep). Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae.

Valerius O, et al. (2001 Feb). Regulation of hisHF transcription of Aspergillus nidulans by adenine and amino acid limitation.

Chaudhuri BN, et al. (2001 Oct). Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites.

Chaudhuri BN, et al. (2003 Jun 17). Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme.

Myers RS, et al. (2003 Jun 17). Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%