FOG01307
EOG8VT4GT

sce:HIS3

Genes: 34

SGD Description
Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p


PomBase Description
imidazoleglycerol-phosphate dehydratase His5


AspGD Description
Imidazoleglycerol-phosphate dehydratase


References

Berlyn MB, et al. (1967 Nov). Gene-enzyme relationships in histidine biosynthesis in Aspergillus nidulans.

Millington-Ward AM, et al. (1970). Recombination and transcription in the hisB and paba1 loci of Aspergillus nidulans.

Struhl K, et al. (1981 Nov 5). Promotor mutants of the yeast his3 gene.

Millington Ward AM, et al. (1984). Bifunctionality and polarized infidelity at the hisB locus of Aspergillus nidulans.

Struhl K, et al. (1985 Dec 9). Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region.

Kitada K, et al. (1995 Nov 20). Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of their disruptant strains by sequential integrative transformation.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Sychrova H, et al. (2000 May). Sequence and organization analyses of a Zygosaccharomyces rouxii DNA fragment containing the HIS3 gene.

Busch S, et al. (2001 Jan). Regulation of the Aspergillus nidulans hisB gene by histidine starvation.

Walsh DW, et al. (2002 Aug). Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.

Leh-Louis V, et al. (2004). Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny.

Bruggeman J, et al. (2004 Feb). Selection arena in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%