FOG01120
EOG83J9KV

sce:LYS4

Genes: 34

SGD Description
Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway


PomBase Description
homoaconitate hydratase Lys2


AspGD Description
Homoaconitate hydratase


References

Kohli J, et al. (1977 Nov). Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Ye ZH, et al. (1988 Dec). Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe.

Wang L, et al. (1989 Jul). Cloning and physical characterization of linked lysine genes (lys4, lys15) of Saccharomyces cerevisiae.

Irvin SD, et al. (1998 Apr). A unique fungal lysine biosynthesis enzyme shares a common ancestor with tricarboxylic acid cycle and leucine biosynthetic enzymes found in diverse organisms.

Hoffman RL, et al. (2006 Jun). Cloning the Schizosaccharomyces pombe lys2+ gene and construction of new molecular genetic tools.

Ma Y, et al. (2007 Aug). Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Fazius F, et al. (2012 Dec). The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%