FOG01117
EOG873N7M
LYS21
sce:LYS21

Genes: 34

Protein description
Mitochondrial homocitrate synthase isozyme


Features
[m]


SGD Description
Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication


PomBase Description
homocitrate synthase


AspGD Description
Homocitrate synthase


References

Kohli J, et al. (1977 Nov). Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Ye ZH, et al. (1988 Dec). Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe.

Perez-Campo FM, et al. (1996 Nov). Cloning and sequencing of the LYS1 gene encoding homocitrate synthase in the yeast Yarrowia lipolytica.

Kwon ES, et al. (2006 Jan 20). Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.

Ma Y, et al. (2007 Aug). Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Bulfer SL, et al. (2009 Dec 18). Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Bulfer SL, et al. (2010 Apr 2). Structural basis for L-lysine feedback inhibition of homocitrate synthase.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Nishida H, et al. (2012). Comparative analyses of homocitrate synthase genes of ascomycetous yeasts.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01118
EOG873N7M
LYS21.2
sce:absent

Genes: 17

Protein description
Cytoplasmic homocitrate synthase isozyme


Features
[c]


Parent
paralog:FOG01117

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01119
EOG873N7M
LYS20
sce:LYS20

Genes: 1

Protein description
Cytoplasmic homocitrate synthase isozym


Features
[c]


Parent
ohnolog:FOG01117


SGD Description
Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication


References

Verhasselt P, et al. (1995 Aug). New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae.

Ramos F, et al. (1996 Oct). Identification of a gene encoding a homocitrate synthase isoenzyme of Saccharomyces cerevisiae.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%