FOG01121
EOG81RN8T

sce:LYS2

Genes: 33

SGD Description
Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p


PomBase Description
aminoadipate-semialdehyde dehydrogenase


AspGD Description
L-aminoadipatesemialdehyde dehydrogenase


References

Fleig UN, et al. (1986). Construction of LYS2 cartridges for use in genetic manipulations of Saccharomyces cerevisiae.

Morris ME, et al. (1991 Feb 1). Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1.

Mannhaupt G, et al. (1992 May). Molecular analysis of yeast chromosome II between CMD1 and LYS2: the excision repair gene RAD16 located in this region belongs to a novel group of double-finger proteins.

Schaaff-Gerstenschläger I, et al. (1993 Oct 1). TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene.

Ehmann DE, et al. (1999 May 11). Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 21 genes with posterior transmembrane prediction > 50%