FOG00871
EOG8PNVXV

sce:VTC4

Genes: 34

SGD Description
Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress


PomBase Description
vacuolar transporter chaperone (VTC) complex subunit (predicted)


AspGD Description
Ortholog(s) have polyphosphate kinase activity and role in microautophagy, polyphosphate metabolic process, vacuolar transport, vacuole fusion, non-autophagic


References

Ogawa N, et al. (2000 Dec). New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

Müller O, et al. (2002 Feb 1). The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation.

Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.

Müller O, et al. (2003 Mar 15). Role of the Vtc proteins in V-ATPase stability and membrane trafficking.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Wild R, et al. (2016 May 20). Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%

FOG00872
EOG8PNVXV

sce:VTC3

Genes: 33

SGD Description
Subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog, VTC2, that arose from the whole genome duplication


PomBase Description
polyphosphate synthetase, VTC complex subunit Vtc2/3 (predicted)


AspGD Description
Ortholog(s) have role in microautophagy, polyphosphate metabolic process, protein localization, vacuolar transport, vacuole fusion, non-autophagic


References

Ogawa N, et al. (2000 Dec). New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

Müller O, et al. (2002 Feb 1). The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation.

Müller O, et al. (2003 Mar 15). Role of the Vtc proteins in V-ATPase stability and membrane trafficking.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wild R, et al. (2016 May 20). Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%

FOG00873
EOG8PNVXV

sce:VTC1

Genes: 32

SGD Description
Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress


PomBase Description
GTPase regulator Nrf1


AspGD Description
Ortholog(s) have GTPase regulator activity, mRNA binding activity


References

Cohen A, et al. (1999 Sep 17). A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins.

Ogawa N, et al. (2000 Dec). New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

Murray JM, et al. (2000 Jan). Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe.

Murray JM, et al. (2001 Feb 2). The Cdc42p GTPase and its regulators Nrf1p and Scd1p are involved in endocytic trafficking in the fission yeast Schizosaccharomyces pombe.

Müller O, et al. (2002 Feb 1). The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation.

Müller O, et al. (2003 Mar 15). Role of the Vtc proteins in V-ATPase stability and membrane trafficking.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%

FOG00874
EOG8PNVXV

sce:VTC2

Genes: 2

SGD Description
Subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog, VTC3, that arose from the whole genome duplication


References

Ogawa N, et al. (2000 Dec). New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

Müller O, et al. (2002 Feb 1). The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation.

Müller O, et al. (2003 Mar 15). Role of the Vtc proteins in V-ATPase stability and membrane trafficking.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wild R, et al. (2016 May 20). Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%