FOG00869
EOG8VDNGT
IPP1
sce:IPP1

Genes: 33

Protein description
Cytoplasmic inorganic pyrophosphatase (PPase)


SGD Description
Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase


PomBase Description
inorganic pyrophosphatase Ipp1 (predicted)


AspGD Description
Inorganic pyrophosphatase


References

Cohen SA, et al. (1978 Feb 10). Covalent structural analysis of yeast inorganic pyrophosphatase.

Bond MW, et al. (1980 Jan 8). Identification of an arginine important for enzymatic activity within the covalent structure of yeast inorganic pyrophosphatase.

Kolakowski LF Jr, et al. (1988 Nov 25). Cloning, molecular characterization and chromosome localization of the inorganic pyrophosphatase (PPA) gene from S. cerevisiae.

Stark MJ, et al. (1989 Jan-Feb). Cloning and analysis of the Kluyveromyces lactis TRP1 gene: a chromosomal locus flanked by genes encoding inorganic pyrophosphatase and histone H3.

Lahti R, et al. (1990 May 8). Conservation of functional residues between yeast and E. coli inorganic pyrophosphatases.

Raznikov AV, et al. (1992 Aug 10). Tyrosine-89 is important for enzymatic activity of S. cerevisiae inorganic pyrophosphatase.

Heikinheimo P, et al. (1996 Dec 15). The structural basis for pyrophosphatase catalysis.

Norbeck J, et al. (1996 Mar 15). Protein expression during exponential growth in 0.7 M NaCl medium of Saccharomyces cerevisiae.

Tuominen V, et al. (1998 Dec 18). The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Kim Y, et al. (2007 Sep). Proteome map of Aspergillus nidulans during osmoadaptation.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Gupta S, et al. (2013 Feb 18). Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00870
EOG8VDNGT
PPA2
sce:PPA2

Genes: 23

Protein description
Mitochondrial inorganic pyrophosphatase


SGD Description
Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate


PomBase Description
mitochondrial inorganic diphosphatase (predicted)


Suggested Analysis
Investigate if protein is absent in some annotations; [m] enzyme is essential in sce


References

Lundin M, et al. (1991 Jul 5). Yeast PPA2 gene encodes a mitochondrial inorganic pyrophosphatase that is essential for mitochondrial function.

Vihinen M, et al. (1992 Jul 15). Computer modeling of two inorganic pyrophosphatases.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%