FOG00875
EOG8BNZTS

sce:PPN1

Genes: 31

SGD Description
Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress


PomBase Description
vacuolar polyphosphatase (predicted)


AspGD Description
Ortholog(s) have endopolyphosphatase activity, exopolyphosphatase activity, role in polyphosphate catabolic process and cytosol, fungal-type vacuole membrane, nucleus localization


References

Bang DD, et al. (1992 Aug 11). Molecular cloning of RAD16, a gene involved in differential repair in Saccharomyces cerevisiae.

Kumble KD, et al. (1996 Oct 25). Endopolyphosphatases for long chain inorganic polyphosphate in yeast and mammals.

Ogawa N, et al. (2000 Dec). New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

Sethuraman A, et al. (2001 Jul 17). The endopolyphosphatase gene: essential in Saccharomyces cerevisiae.

Reggiori F, et al. (2001 Sep 17). Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting.

Reggiori F, et al. (2002 Feb). A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies.

Andreeva NA, et al. (2004 Apr). Purification and properties of exopolyphosphatase from the cytosol of Saccharomyces cerevisiae not encoded by the PPX1 gene.

Morvan J, et al. (2004 May). The ubiquitin ligase Rsp5p is required for modification and sorting of membrane proteins into multivesicular bodies.

Lichko L, et al. (2004 Sep 6). Inactivation of endopolyphosphatase gene PPN1 results in inhibition of expression of exopolyphosphatase PPX1 and high-molecular-mass exopolyphosphatase not encoded by PPX1 in Saccharomyces cerevisiae.

Shi X, et al. (2005 Mar 28). Endopolyphosphatase in Saccharomyces cerevisiae undergoes post-translational activations to produce short-chain polyphosphates.

Andreeva NA, et al. (2006 Sep). High molecular mass exopolyphosphatase from the cytosol of the yeast Saccharomyces cerevisiae is encoded by the PPN1 gene.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Henry TC, et al. (2011 Feb). Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Andreeva N, et al. (2015). Polyphosphatase PPN1 of Saccharomyces cerevisiae: switching of exopolyphosphatase and endopolyphosphatase activities.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 13 genes with posterior transmembrane prediction > 50%