FOG00772
EOG8ZCRR8

sce:COA6

Genes: 32

Protein description
COX.assembly


SGD Description
Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress


PomBase Description
cytochrome c oxidase subunit VIb-related protein (predicted)


AspGD Description
Ortholog(s) have role in cellular copper ion homeostasis, mitochondrial respiratory chain complex IV assembly and mitochondrial intermembrane space, nucleus localization


References

Cavallaro G, et al. (2010 Dec). Genome-wide analysis of eukaryotic twin CX9C proteins.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Ghosh A, et al. (2014 Jul 1). Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency.

Pacheu-Grau D, et al. (2015 Jun 2). Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%