FOG00771
EOG88GTMJ

sce:SHY1

Genes: 32

Protein description
COX.assembly


SGD Description
Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase


PomBase Description
cytochrome c oxidase assembly protein Shy1 (predicted)


AspGD Description
Ortholog(s) have mitochondrion, plasma membrane localization


References

Mashkevich G, et al. (1997 May 30). SHY1, the yeast homolog of the mammalian SURF-1 gene, encodes a mitochondrial protein required for respiration.

Barrientos A, et al. (2002 Jan 15). Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Mick DU, et al. (2007 Oct 17). Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.

Pierrel F, et al. (2007 Oct 17). Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.

Pierrel F, et al. (2008 Aug). Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%