FOG00651
EOG889379
FUM1
sce:FUM1

Genes: 26

Protein description
Cytoplasmic and mitochondrial fumarase


SGD Description
Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria


PomBase Description
fumarate hydratase (predicted)


AspGD Description
Fumarate hydratase


References

Wu M, et al. (1987 Sep 5). Mitochondrial and cytoplasmic fumarases in Saccharomyces cerevisiae are encoded by a single nuclear gene FUM1.

Peleg Y, et al. (1990 Sep). Inducible overexpression of the FUM1 gene in Saccharomyces cerevisiae: localization of fumarase and efficient fumaric acid bioconversion to L-malic acid.

Stein I, et al. (1994 Jul). The single translation product of the FUM1 gene (fumarase) is processed in mitochondria before being distributed between the cytosol and mitochondria in Saccharomyces cerevisiae.

Weaver T, et al. (1998 Jul 17). Crystal structures of native and recombinant yeast fumarase.

Knox C, et al. (1998 Oct 2). Import into mitochondria, folding and retrograde movement of fumarase in yeast.

Karlberg O, et al. (2000 Sep 30). The dual origin of the yeast mitochondrial proteome.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00652
EOG889379
FUM1.2
sce:absent

Genes: 8

Protein description
Uncharacterized mitochondrial fumarase


Features
[m]


Parent
paralog:FOG00651

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00653
EOG889379
FUM2
sce:absent

Genes: 7

Protein description
Uncharacterized cytoplasmic fumarase


Features
[c]


Parent
paralog:FOG00651

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00654
EOG889379
FUM2.2
sce:absent

Genes: 1

Protein description
Uncharacterized fumarase paralog

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%