FOG00655
EOG8NGF48
MDH1
sce:MDH1

Genes: 34

Protein description
Mitochondrial malate dehydrogenase


Features
[m]


SGD Description
Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated


PomBase Description
malate dehydrogenase Mdh1 (predicted)


AspGD Description
Mitochondrial malate dehydrogenase


References

Kopetzki E, et al. (1987 Apr 30). Purification procedure and N-terminal amino acid sequence of yeast malate dehydrogenase isoenzymes.

Thompson LM, et al. (1988 Nov 1). Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Gerke J, et al. (2012 Jun). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Burr R, et al. (2017 Sep 29). Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00656
EOG8NGF48
MDH2
sce:absent

Genes: 9

Protein description
Cytoplasmic and peroxisomal malate dehydrogenase (via alternative splicing in yli)


Features
[c]/[x]


AspGD Description
Malate dehydrogenase precursor


References

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Oh YT, et al. (2010 Mar). Proteomic analysis of early phase of conidia germination in Aspergillus nidulans.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Kabran P, et al. (2012 Jun). Alternative splicing regulates targeting of malate dehydrogenase in Yarrowia lipolytica.

Suzuki Y, et al. (2012 Jun). Reprogramming of carbon metabolism by the transcriptional activators AcuK and AcuM in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00657
EOG8NGF48
MDH2.2
sce:absent

Genes: 17

Protein description
Cytoplasmic malate dehydrogenase


Features
[c]


References

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00658
EOG8NGF48
MDH3
sce:MDH3

Genes: 20

Protein description
Peroxisomal malate dehydrogenase


Features
[x]


SGD Description
Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle


References

van Urk H, et al. (1989 Jul 21). Localization and kinetics of pyruvate-metabolizing enzymes in relation to aerobic alcoholic fermentation in Saccharomyces cerevisiae CBS 8066 and Candida utilis CBS 621.

Minard KI, et al. (1991 Jan). Isolation, nucleotide sequence analysis, and disruption of the MDH2 gene from Saccharomyces cerevisiae: evidence for three isozymes of yeast malate dehydrogenase.

Steffan JS, et al. (1992 Dec 5). Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase.

McAlister-Henn L, et al. (1995 Sep 8). Expression and function of a mislocalized form of peroxisomal malate dehydrogenase (MDH3) in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00659
EOG8NGF48

sce:absent

Genes: 1

Protein description
Uncharacterized malate dehydrogenase


Parent
paralog:FOG00656


AspGD Description
Malate dehydrogenase


References

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Suzuki Y, et al. (2012 Jun). Reprogramming of carbon metabolism by the transcriptional activators AcuK and AcuM in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00660
EOG802V8D
MDH2.3
sce:MDH2

Genes: 5

Protein description
Cytoplasmic malate dehydrogenase


Features
[c]


SGD Description
Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1


Suggested Analysis
Investigate if belongs to FOG00657


References

Neeff J, et al. (1977 Oct 24). In vivo and in vitro studies on the glucose dependent inactivation of yeast cytoplasmic malate dehydrogenase.

Kopetzki E, et al. (1987 Apr 30). Purification procedure and N-terminal amino acid sequence of yeast malate dehydrogenase isoenzymes.

Minard KI, et al. (1991 Jan). Isolation, nucleotide sequence analysis, and disruption of the MDH2 gene from Saccharomyces cerevisiae: evidence for three isozymes of yeast malate dehydrogenase.

Minard KI, et al. (1992 Aug 25). Glucose-induced degradation of the MDH2 isozyme of malate dehydrogenase in yeast.

Steffan JS, et al. (1992 Dec 5). Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00661
EOG802V8D

sce:absent

Genes: 1

Protein description
Uncharacterized malate dehydrogenase


Parent
ohnolog:FOG00660


Suggested Analysis
Investigate N-terminal hydrophobic residues

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%