FOG00646
EOG883BM0
OSM2
sce:absent

Genes: 16

Protein description
Fumarate reductase; unknown role of C-terminal peptide


AspGD Description
Succinate dehydrogenase


References

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00647
EOG883BM0
OSM1
sce:OSM1

Genes: 20

Protein description
Fumarate reductase; ER-tag,[c]/[m] depending on mRNA start codon


Parent
paralog:FOG00646


SGD Description
Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication


Suggested Analysis
Premature start codon in HVA


References

Singh A, et al. (1978 Aug). Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity.

Huang ME, et al. (1994 Jun). Revised nucleotide sequence of the COR region of yeast Saccharomyces cerevisiae chromosome X.

Enomoto K, et al. (1996 Aug 31). Cloning and sequencing of the gene encoding the soluble fumarate reductase from Saccharomyces cerevisiae.

Muratsubaki H, et al. (1998 Apr 15). One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene.

Arikawa Y, et al. (1998 Aug 1). Soluble fumarate reductase isoenzymes from Saccharomyces cerevisiae are required for anaerobic growth.

Camarasa C, et al. (2003 Sep). Investigation by 13C-NMR and tricarboxylic acid (TCA) deletion mutant analysis of pathways for succinate formation in Saccharomyces cerevisiae during anaerobic fermentation.

Camarasa C, et al. (2007 May). Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG00648
EOG883BM0
OSM1.2
sce:absent

Genes: 1

Protein description
Fumarate reductase [c] has intron; ORFeome suggests [m] > [c]=[n]


Parent
xenolog:FOG00647


PomBase Description
fumarate reductase Osm1 (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00649
EOG883BM0
OSM1.3
sce:absent

Genes: 2

Protein description
Fumarate reductase, horizontal gene transfer from Pichia clade species


Parent
xenolog:FOG00647


AspGD Description
Putative fumarate reductase


References

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00650
EOG883BM0
FRD1
sce:FRD1

Genes: 2

Protein description
Soluble fumarate reductase ohnolog; strong evidence for signal peptide


Parent
ohnolog:FOG00647


SGD Description
Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication


References

Enomoto K, et al. (1996 Aug 31). Cloning and sequencing of the gene encoding the soluble fumarate reductase from Saccharomyces cerevisiae.

Muratsubaki H, et al. (1998 Apr 15). One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene.

Arikawa Y, et al. (1998 Aug 1). Soluble fumarate reductase isoenzymes from Saccharomyces cerevisiae are required for anaerobic growth.

Camarasa C, et al. (2003 Sep). Investigation by 13C-NMR and tricarboxylic acid (TCA) deletion mutant analysis of pathways for succinate formation in Saccharomyces cerevisiae during anaerobic fermentation.

Camarasa C, et al. (2007 May). Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%