FOG00643
EOG82BVVW
SDH4
sce:SDH4

Genes: 33

Protein description
Membrane anchor subunit of succinate dehydrogenase (SDH)


SGD Description
Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma


PomBase Description
TIM22 inner membrane protein import complex anchor subunit Tim18


AspGD Description
Succinate dehydrogenase


References

Bullis BL, et al. (1994 Mar 4). Isolation and characterization of the Saccharomyces cerevisiae SDH4 gene encoding a membrane anchor subunit of succinate dehydrogenase.

Oyedotun KS, et al. (2001 May 18). The Quinone-binding sites of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase.

Lemire BD, et al. (2002 Jan 17). The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase.

Oyedotun KS, et al. (2004 Mar 5). Identification of the heme axial ligands in the cytochrome b562 of the Saccharomyces cerevisiae succinate dehydrogenase.

Oyedotun KS, et al. (2004 Mar 5). The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies.

Silkin Y, et al. (2007 Feb). The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG00644
EOG82BVVW
TIM18
sce:TIM18

Genes: 22

Protein description
Component of the mitochondrial TIM22 complex


Parent
paralog:FOG00643


SGD Description
Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex


References

Koehler CM, et al. (2000 Feb). Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane.

Kerscher O, et al. (2000 Jan). Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane.

Rehling P, et al. (2003 Mar 14). Protein insertion into the mitochondrial inner membrane by a twin-pore translocase.

Dunn CD, et al. (2003 Sep). Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%

FOG00645

SHH4
sce:SHH4

Genes: 1

Protein description
SDH4 ohnolog, unknown function but can substitute activity


Parent
ohnolog:FOG00643


SGD Description
Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p


References

Kerscher O, et al. (2000 Jan). Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Gebert N, et al. (2011 Dec 9). Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%