FOG00617
EOG8S4MZ6
IDP0
sce:absent

Genes: 8

Protein description
Cytoplasmic, mitochondrial, peroxisomal isocitrate dehydrogenase


Features
[c];[m];[x]


AspGD Description
NADP+-specific isocitrate dehydrogenase; induced by growth on starch and lactate


Suggested Analysis
[m]-tag missing in arx ortholog


References

Kelly JM, et al. (1982 Jan). The regulation of NADP-linked isocitrate dehydrogenase in Aspergillus nidulans.

Szewczyk E, et al. (2001 Oct 5). A single gene produces mitochondrial, cytoplasmic, and peroxisomal NADP-dependent isocitrate dehydrogenase in Aspergillus nidulans.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions FOG00617 0 FOG00617 0 Name: 1, dtype: int64 genes with posterior transmembrane prediction > 50%

FOG00618
EOG8S4MZ6
IDP1
sce:absent

Genes: 21

Protein description
Cytoplasmic, peroxisomal isocitrate dehydrogenase derived from IDP0


Features
[c];[x]


Parent
ortholog:FOG00617

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00619
EOG8S4MZ6
IDP2
sce:IDP2

Genes: 1

Protein description
Cytoplasmic isocitrate dehydrogenase


Features
[c];NADP


Parent
ortholog:FOG00617


SGD Description
Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication


References

Haselbeck RJ, et al. (1993 Jun 5). Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases.

Loftus TM, et al. (1994 Aug 16). Isolation, characterization, and disruption of the yeast gene encoding cytosolic NADP-specific isocitrate dehydrogenase.

Henke B, et al. (1998 Feb 6). IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids.

Szewczyk E, et al. (2001 Oct 5). A single gene produces mitochondrial, cytoplasmic, and peroxisomal NADP-dependent isocitrate dehydrogenase in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00620
EOG8S4MZ6
IDP3
sce:IDP3

Genes: 1

Protein description
Peroxisomal isocitrate dehydrogenase


Features
[x]


Parent
ohnolog?:FOG00619


SGD Description
Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00621
EOG8S4MZ6
IDP1.2
sce:IDP1

Genes: 24

Protein description
Mitochondrial isocitrate dehydrogenase


Features
[m]


Parent
paralog:FOG00617


SGD Description
Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes


References

Bernofsky C, et al. (1966 Nov 25). Mitochondrial isocitrate dehydrogenases from yeast.

Haselbeck RJ, et al. (1991 Feb 5). Isolation, nucleotide sequence, and disruption of the Saccharomyces cerevisiae gene encoding mitochondrial NADP(H)-specific isocitrate dehydrogenase.

Haselbeck RJ, et al. (1993 Jun 5). Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases.

Loftus TM, et al. (1994 Aug 16). Isolation, characterization, and disruption of the yeast gene encoding cytosolic NADP-specific isocitrate dehydrogenase.

Henke B, et al. (1998 Feb 6). IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids.

Kirimura K, et al. (2002). Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial NADP+-specific isocitrate dehydrogenase.

Nosek J, et al. (2006 May). Mitochondrial chromosome structure: an insight from analysis of complete yeast genomes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00622
EOG8S4MZ6
IDP1.3
sce:absent

Genes: 1

Protein description
Mitochondrial isocitrate dehydrogenase


Features
[m]


Parent
ortholog:FOG00617


PomBase Description
isocitrate dehydrogenase Idp1 (predicted)


References

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Burr R, et al. (2017 Sep 29). Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%