FOG00623
EOG8V41R6
IDH1
sce:IDH1

Genes: 33

Protein description
Alpha subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase


SGD Description
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle


PomBase Description
isocitrate dehydrogenase (NAD+) subunit 1 Idh1


AspGD Description
Putative isocitrate dehydrogenase (NAD+)


Suggested Analysis
Investigate origin of duplication


References

Keys DA, et al. (1990 Aug). Subunit structure, expression, and function of NAD(H)-specific isocitrate dehydrogenase in Saccharomyces cerevisiae.

Cupp JR, et al. (1992 Aug 15). Cloning and characterization of the gene encoding the IDH1 subunit of NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces cerevisiae.

Barel I, et al. (1993 Nov 1). Enzyme defects in glutamate-requiring strains of Schizosaccharomyces pombe.

Elzinga SD, et al. (1993 Nov 25). Yeast mitochondrial NAD(+)-dependent isocitrate dehydrogenase is an RNA-binding protein.

Elzinga SD, et al. (2000 Aug). Isolation and RNA-binding analysis of NAD+ -isocitrate dehydrogenases from Kluyveromyces lactis and Schizosaccharomyces pombe.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Du W, et al. (2012 Sep 15). TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00624
EOG8V41R6
IDH2
sce:IDH2

Genes: 35

Protein description
Beta subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase


SGD Description
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated


PomBase Description
isocitrate dehydrogenase (NAD+) subunit 2


AspGD Description
Putative isocitrate dehydrogenase (NAD+)


Suggested Analysis
Investigate origin of duplication


References

Keys DA, et al. (1990 Aug). Subunit structure, expression, and function of NAD(H)-specific isocitrate dehydrogenase in Saccharomyces cerevisiae.

Cupp JR, et al. (1991 Nov 25). NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae.

Elzinga SD, et al. (1993 Nov 25). Yeast mitochondrial NAD(+)-dependent isocitrate dehydrogenase is an RNA-binding protein.

Elzinga SD, et al. (2000 Aug). Isolation and RNA-binding analysis of NAD+ -isocitrate dehydrogenases from Kluyveromyces lactis and Schizosaccharomyces pombe.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Martins I, et al. (2013 Dec 6). Proteomic alterations induced by ionic liquids in Aspergillus nidulans and Neurospora crassa.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00625
EOG8V41R6
LYS12
sce:LYS12

Genes: 33

Protein description
Homo-isocitrate dehydrogenase


Features
[m];NAD


Parent
paralog:FOG00624


SGD Description
Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate


PomBase Description
homoisocitrate dehydrogenase Lys12


AspGD Description
Ortholog(s) have NAD binding, homoisocitrate dehydrogenase activity, role in lysine biosynthetic process and mitochondrion localization


References

Käfer E, et al. (1965 Jul). Origins of translocations in Aspergillus nidulans.

Strassman M, et al. (1965 Nov). Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.

Rowley B, et al. (1970 Dec). Homoisocitric dehydrogenase from yeast.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Bal J, et al. (1979 Dec). Allele specific and locus non-specific suppressors in Aspergillus nidulans.

Urrestarazu LA, et al. (1985). General and specific controls of lysine biosynthesis in Saccharomyces cerevisiae.

Donnelly E, et al. (1994 Nov 28). Germinating conidiospores of Aspergillus amino acid auxotrophs are hypersensitive to heat shock, oxidative stress and DNA damage.

Shevchenko A, et al. (1996 Dec 10). Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Bruggeman J, et al. (2004 Feb). Selection arena in Aspergillus nidulans.

Mogensen J, et al. (2006 Aug). Transcription analysis using high-density micro-arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol.

Lin Y, et al. (2007 Jan 23). Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.

Lin Y, et al. (2009 Aug 4). Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.

Kim JM, et al. (2015 Jan). Characterization of NpgA, a 4'-phosphopantetheinyl transferase of Aspergillus nidulans, and evidence of its involvement in fungal growth and formation of conidia and cleistothecia for development.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00626
EOG8V41R6
LYS12.2
sce:LYS12.2

Genes: 1

Protein description
Uncharacterized paralog


Parent
paralog:FOG00625

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%