FOG00614
EOG802V74
ACO1
sce:ACO1

Genes: 34

Protein description
ACO alpha subunit


SGD Description
Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; human homolog ACO2 complements yeast null mutant


PomBase Description
aconitate hydratase Aco1 (predicted)


AspGD Description
Mitochondrial aconitate hydratase


References

Gangloff SP, et al. (1990 Jul). Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Przybyla-Zawislak B, et al. (1999 May). Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.

Pardo M, et al. (2000 Jul). Cross-species identification of novel Candida albicans immunogenic proteins by combination of two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.

Oberegger H, et al. (2002 Nov). Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans.

Haas H, et al. (2003 Sep). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage.

Chen XJ, et al. (2005 Feb 4). Aconitase couples metabolic regulation to mitochondrial DNA maintenance.

Regev-Rudzki N, et al. (2005 Sep). Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.

Chen XJ, et al. (2007 Aug 21). Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.

Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Regev-Rudzki N, et al. (2008 Jul 15). The mitochondrial targeting sequence tilts the balance between mitochondrial and cytosolic dual localization.

Lin AP, et al. (2008 Jun 1). Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase.

Wallner A, et al. (2009 Jun). Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Roberts-Galbraith RH, et al. (2010 Jul 9). Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Oh YT, et al. (2010 Mar). Proteomic analysis of early phase of conidia germination in Aspergillus nidulans.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Ben-Menachem R, et al. (2011 Jun 3). The aconitase C-terminal domain is an independent dual targeting element.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Fazius F, et al. (2012 Dec). The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.

Gerke J, et al. (2012 Jun). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.

Farooq MA, et al. (2013). Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Metodiev MD, et al. (2014 Dec). Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Jung SJ, et al. (2015 Mar 24). Essential function of Aco2, a fusion protein of aconitase and mitochondrial ribosomal protein bL21, in mitochondrial translation in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00615
EOG802V74
ACO2
sce:ACO2

Genes: 33

Protein description
ACO beta subunit


SGD Description
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol


PomBase Description
aconitate hydratase/mitochondrial ribosomal protein subunit L21, fusion protein


AspGD Description
Putative aconitate hydratase


References

Przybyla-Zawislak B, et al. (1999 May). Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Fazius F, et al. (2012 Dec). The fungal α-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00616
EOG802V74
EOG81G1K5

sce:absent

Genes: 2

Parent
paralog:FOG00615


AspGD Description
Aconitate hydratase|Putative mitochondrial aconitase


References

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%