FOG00301
EOG8VQ874
GAL10
sce:absent

Genes: 10

Protein description
UDP-glucose-4-epimerase; contains epimerase domain, unlike sce homolog which contains mutarotase domain; likely plays a more dominant role in glycosylation (spo); spo ortholog expressed in glucose rich conditions


Features
Contains epimerase domain


PomBase Description
UDP-glucose 4-epimerase Uge1


AspGD Description
UDP-glucose 4-epimerase; Leloir pathway enzyme


References

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

El-Ganiny AM, et al. (2010 Jul). Aspergillus nidulans UDP-glucose-4-epimerase UgeA has multiple roles in wall architecture, hyphal morphogenesis, and asexual development.

Suzuki S, et al. (2010 Mar). Characterization of two different types of UDP-glucose/-galactose 4-epimerase involved in galactosylation in fission yeast.

Ma Y, et al. (2011). Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Buttrick GJ, et al. (2011 Dec). Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Paul BC, et al. (2011 May). Quantifying the importance of galactofuranose in Aspergillus nidulans hyphal wall surface organization by atomic force microscopy.

Etxebeste O, et al. (2012). GmcA is a putative glucose-methanol-choline oxidoreductase required for the induction of asexual development in Aspergillus nidulans.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Alam MK, et al. (2012 Dec). Aspergillus nidulans galactofuranose biosynthesis affects antifungal drug sensitivity.

Dalrymple SA, et al. (2013). Elucidation of substrate specificity in Aspergillus nidulans UDP-galactose-4-epimerase.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Matsuzawa T, et al. (2013 Jun). Ght2⁺ is required for UDP-galactose synthesis from extracellular galactose by Schizosaccharomyces pombe.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rak M, et al. (2014 May). X-ray microfluorescence (μXRF) imaging of Aspergillus nidulans cell wall mutants reveals biochemical changes due to gene deletions.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Gaspa L, et al. (2016). A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00302
EOG8VQ874
GAL10.2
sce:GAL10

Genes: 17

Protein description
UDP-glucose-4-epimerase from Proto-fermenter lineage; absent in aru and some Pichia clade species


Features
Contains epimerase and mutarotase domain


Parent
paralog:FOG00301


SGD Description
UDP-glucose-4-epimerase; catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Citron BA, et al. (1984 Apr). Sequence of the Saccharomyces GAL region and its transcription in vivo.

Johnston M, et al. (1984 Aug). Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

Tajima M, et al. (1985 Sep). Primary structure of the Saccharomyces cerevisiae GAL7 gene.

Bajwa W, et al. (1988 Aug). Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases.

Webster TD, et al. (1988 Aug 25). Nucleotide sequence of the galactose gene cluster of Kluyveromyces lactis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00303
EOG8VQ874
GAL10.3
sce:absent

Genes: 1

Protein description
SPO xenolog expressed in glucose derepressed conditions


Parent
xenolog:FOG00302


PomBase Description
UDP-glucose 4-epimerase/aldose 1-epimerase Gal10

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00304
EOG8VQ874
GAL10.4
sce:absent

Genes: 3

Protein description
Uncharacterized UDP-glucose-4-epimerase isomerase


Parent
paralog:FOG00301


AspGD Description
Ortholog(s) have UDP-N-acetylglucosamine 4-epimerase activity, UDP-glucose 4-epimerase activity and role in galactose metabolic process|UDP-glucose 4-epimerase


References

Coradetti ST, et al. (2013 Aug). Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00305
EOG8VQ874

sce:absent

Genes: 2

SGD Description
Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions|Putative aldose 1-epimerase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00306
EOG8VQ874
GUK1
sce:GUK1

Genes: 33

Protein description
Guanylate kinase


SGD Description
Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins


PomBase Description
guanylate kinase (predicted)


AspGD Description
Guanylate kinase


References

Berger A, et al. (1989 Sep 15). Guanylate kinase from Saccharomyces cerevisiae. Isolation and characterization, crystallization and preliminary X-ray analysis, amino acid sequence and comparison with adenylate kinases.

Stehle T, et al. (1990 Jan 5). Three-dimensional structure of the complex of guanylate kinase from yeast with its substrate GMP.

Stehle T, et al. (1992 Apr 20). Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution.

Konrad M, et al. (1992 Dec 25). Cloning and expression of the essential gene for guanylate kinase from yeast.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Schinko T, et al. (2010 Nov). Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00307
EOG8VQ874

sce:absent

Genes: 2

AspGD Description
Guanylate kinase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00308
EOG8VQ874

sce:absent

Genes: 10

Protein description
THO complex subunit Tho1 (predicted)


PomBase Description
THO complex subunit Tho1 (predicted)


AspGD Description
Ortholog(s) have nucleus localization


References

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%