FOG00298
EOG8K3JC0
CDC19
sce:CDC19

Genes: 34

Protein description
Pyruvate kinase


SGD Description
Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication


PomBase Description
pyruvate kinase


AspGD Description
Pyruvate kinase


References

Burke RL, et al. (1983 Feb 25). The isolation, characterization, and sequence of the pyruvate kinase gene of Saccharomyces cerevisiae.

McNally T, et al. (1989 Apr 24). The yeast pyruvate kinase gene does not contain a string of non-preferred codons: revised nucleotide sequence.

Strick CA, et al. (1992 Sep 1). The isolation and characterization of the pyruvate kinase-encoding gene from the yeast Yarrowia lipolytica.

Swoboda RK, et al. (1993 Oct). Glycolytic enzymes of Candida albicans are nonubiquitous immunogens during candidiasis.

Strick CA, et al. (1994 Mar 11). The isolation and characterization of the pyruvate kinase-encoding gene from the yeast Yarrowia lipolytica.

Jurica MS, et al. (1998 Feb 15). The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.

Bollenbach TJ, et al. (1999 Jul 13). Role of lysine 240 in the mechanism of yeast pyruvate kinase catalysis.

Pardo M, et al. (2000 Jul). Cross-species identification of novel Candida albicans immunogenic proteins by combination of two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.

Langkjaer RB, et al. (2003 Feb 20). Yeast genome duplication was followed by asynchronous differentiation of duplicated genes.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Aa E, et al. (2006 Aug). Population structure and gene evolution in Saccharomyces cerevisiae.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00299
EOG8K3JC0
PYK2
sce:PYK2

Genes: 1

Protein description
Pyruvate kinase ohnolog


Parent
ohnolog:FOG00298


SGD Description
Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication


References

Boles E, et al. (1997 May). Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00300

PYK3
sce:absent

Genes: 1

Protein description
Uncharacterized pyruvate kinase paralog


Parent
paralog:FOG00298

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%