FOG00309
EOG8RXWGV
FBP1
sce:FBP1

Genes: 36

Protein description
Fructose-1,6-bisphosphatase


SGD Description
Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p


PomBase Description
fructose-1,6-bisphosphatase Fbp1


AspGD Description
Fructose-2,6-bisphosphatase


Suggested Analysis
Find function of Pichia and Ascoidea paralogs.


References

Armitt S, et al. (1976 Feb). Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans.

Payton M, et al. (1976 May). Agar as a carbon source and its effect on the utilization of other carbon sources by acetate non-utilizing (acu) mutants of Aspergillus nidulans.

Vassarotti A, et al. (1985 May 25). Isolation of the fructose-1,6-bisphosphatase gene of the yeast Schizosaccharomyces pombe. Evidence for transcriptional regulation.

Marcus F, et al. (1986 Mar 13). Amino acid sequence homology among fructose-1,6-bisphosphatases.

Entian KD, et al. (1988 Aug 15). Isolation and primary structure of the gene encoding fructose-1,6-bisphosphatase from Saccharomyces cerevisiae.

Rogers DT, et al. (1988 May 5). Characterization of the gene for fructose-1,6-bisphosphatase from Saccharomyces cerevisiae and Schizosaccharomyces pombe. Sequence, protein homology, and expression during growth on glucose.

Hoffman CS, et al. (1989 Dec 14). A transcriptionally regulated expression vector for the fission yeast Schizosaccharomyces pombe.

Hoffman CS, et al. (1990 Apr). Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.

Hoffman CS, et al. (1991 Apr). Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Zaror I, et al. (1993 Feb 15). Fructose-1,6-bisphosphatase of the yeast Kluyveromyces lactis.

Nocero M, et al. (1994 Sep). Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Wu SY, et al. (1995 Mar). The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.

Watanabe Y, et al. (1996 Feb). Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development.

Stettler S, et al. (1996 Jul). The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Schweingruber AM, et al. (1998 Dec). Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway.

Welton RM, et al. (2000 Oct). Glucose monitoring in fission yeast via the Gpa2 galpha, the git5 Gbeta and the git3 putative glucose receptor.

Janoo RT, et al. (2001 Mar). Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Higuchi T, et al. (2002 Jan). Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast.

Hynes MJ, et al. (2002 Jan). Regulation of the acuF gene, encoding phosphoenolpyruvate carboxykinase in the filamentous fungus Aspergillus nidulans.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Sims AH, et al. (2004 Feb). Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans.

Hynes MJ, et al. (2007 May). Transcriptional control of gluconeogenesis in Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Alaamery MA, et al. (2008 Apr). Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Roux AE, et al. (2009 Mar). Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

Ivey FD, et al. (2010 Apr). Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

Kang WH, et al. (2010 Apr 30). The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Matsuzawa T, et al. (2012 Feb). Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.

Matsuzawa T, et al. (2012 Jul). Promotion of glycerol utilization using ethanol and 1-propanol in Schizosaccharomyces pombe.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Kato H, et al. (2013). The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.

Mudge DK, et al. (2014 Feb). Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%