FOG00258
EOG8G1K38

sce:RPB4

Genes: 31

Protein description
RNA polymerase subunit


SGD Description
RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation


PomBase Description
DNA-directed RNA polymerase II complex subunit Rpb4


AspGD Description
DNA-directed RNA polymerase


References

Woychik NA, et al. (1989 Jul). RNA polymerase II subunit RPB4 is essential for high- and low-temperature yeast cell growth.

Edwards AM, et al. (1991 Jan 5). Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro.

Foreman PK, et al. (1991 May 25). The Saccharomyces cerevisiae RPB4 gene is tightly linked to the TIF2 gene.

Pillai B, et al. (2001 Aug 17). Rpb4, a non-essential subunit of core RNA polymerase II of Saccharomyces cerevisiae is important for activated transcription of a subset of genes.

Orlicky SM, et al. (2001 Mar 30). Dissociable Rpb4-Rpb7 subassembly of rna polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation.

Li S, et al. (2002 Nov 1). Rpb4 and Rpb9 mediate subpathways of transcription-coupled DNA repair in Saccharomyces cerevisiae.

Kettenberger H, et al. (2003 Aug 8). Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage.

Farago M, et al. (2003 Jul). Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress.

Armache KJ, et al. (2003 Jun 10). Architecture of initiation-competent 12-subunit RNA polymerase II.

Chung WH, et al. (2003 Oct). RNA polymerase II/TFIIF structure and conserved organization of the initiation complex.

Kamenski T, et al. (2004 Aug 13). Structure and mechanism of RNA polymerase II CTD phosphatases.

Kettenberger H, et al. (2004 Dec 22). Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS.

Lotan R, et al. (2005 Dec 15). The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs.

Armache KJ, et al. (2005 Feb 25). Structures of complete RNA polymerase II and its subcomplex, Rpb4/7.

Selitrennik M, et al. (2006 Dec). Nucleocytoplasmic shuttling of the Rpb4p and Rpb7p subunits of Saccharomyces cerevisiae RNA polymerase II by two pathways.

Kettenberger H, et al. (2006 Jan). Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs.

Meyer PA, et al. (2006 Jun). Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%