FOG00230
EOG80P2NK

sce:MIP1

Genes: 31

Protein description
DNA polymerase mito


SGD Description
Mitochondrial DNA polymerase gamma subunit; conserved C-terminus required for mitochondrial genome maintenance; human ortholog POLG rescues mip1 phenotypes; mutations in POLG associated with Alpers-Huttenlocher syndrome (AHS), other mitochondrial diseases; Mip1p is single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in S.cerevisiae such that Petites occur more frequently in some lab strains


PomBase Description
mitochondrial DNA polymerase gamma


AspGD Description
DNA-directed DNA polymerase


References

Foury F, et al. (1989 Dec 5). Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase.

Ye F, et al. (1996 Apr 15). The gamma subfamily of DNA polymerases: cloning of a developmentally regulated cDNA encoding Xenopus laevis mitochondrial DNA polymerase gamma.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Davidzon G, et al. (2005 Jun). POLG mutations and Alpers syndrome.

Chu Z, et al. (2007 Sep 15). Adaptive expression responses in the Pol-gamma null strain of S. pombe depleted of mitochondrial genome.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Kim DM, et al. (2016 Jan). Identification of a Mitochondrial DNA Polymerase Affecting Cardiotoxicity of Sunitinib Using a Genome-Wide Screening on S. pombe Deletion Library.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%