FOG00229
EOG8H44JK

sce:DNA2

Genes: 21

Protein description
DNA polymerase


SGD Description
Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair and processing of meiotic DNA double strand breaks; required for normal life span; component of telomeric chromatin, with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress


PomBase Description
DNA replication endonuclease-helicase Dna2


AspGD Description
Ortholog(s) have 5' overhang single-stranded DNA endodeoxyribonuclease activity, 5'-flap endonuclease activity, ATP-dependent DNA helicase activity and chromatin binding, more


References

Budd ME, et al. (1995 Aug 15). A yeast gene required for DNA replication encodes a protein with homology to DNA helicases.

Bae SH, et al. (1998 Oct 9). Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP.

Kao HI, et al. (2004 Dec 3). Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation.

Zhu Z, et al. (2008 Sep 19). Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.

Balakrishnan L, et al. (2010 Dec 10). Dna2 exhibits a unique strand end-dependent helicase function.

Cejka P, et al. (2010 Sep 2). DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.

Chen X, et al. (2011 Aug 14). Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pokharel S, et al. (2012 Sep). Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%