FOG00228
EOG8VHHNH

sce:FUN30

Genes: 35

Protein description
DNA polymerase


SGD Description
Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate


PomBase Description
SMARCAD1 family ATP-dependent DNA helicase Fft1 (predicted)|SMARCAD1 family ATP-dependent DNA helicase Fft2 (predicted)|SMARCAD1 family ATP-dependent DNA helicase Fft3


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Barton AB, et al. (1994 Apr). Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region.

Neves-Costa A, et al. (2009 Dec 1). The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci.

Awad S, et al. (2010 Mar 26). The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme.

Eapen VV, et al. (2012 Nov). The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation.

Durand-Dubief M, et al. (2012 Sep). SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae.

Chen X, et al. (2012 Sep 27). The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends.

Costelloe T, et al. (2012 Sep 27). The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.

Zhou H, et al. (2015 Oct). Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%