FOG00226
EOG83XSKR

sce:POL4

Genes: 23

Protein description
DNA polymerase IV


SGD Description
DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta


AspGD Description
DNA-directed DNA polymerase


References

Bork P, et al. (1992 Dec). Comprehensive sequence analysis of the 182 predicted open reading frames of yeast chromosome III.

Prasad R, et al. (1993 Nov 25). Yeast open reading frame YCR14C encodes a DNA beta-polymerase-like enzyme.

Leem SH, et al. (1994 Aug 11). The yeast Saccharomyces cerevisiae DNA polymerase IV: possible involvement in double strand break DNA repair.

Wilson TE, et al. (1999 Aug 13). Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway.

Tseng HM, et al. (2002 Nov 22). A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00227
EOG83XSKR

sce:absent

Genes: 7

Protein description
DNA polymerase


Parent
paralog:FOG00226


PomBase Description
DNA polymerase X family


AspGD Description
Ortholog(s) have 5'-deoxyribose-5-phosphate lyase activity, DNA primase activity, DNA-directed DNA polymerase activity


References

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

González-Barrera S, et al. (2005). Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.

Coulon S, et al. (2010 Jun 16). Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast.

Li P, et al. (2012 Feb 1). Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Li J, et al. (2014 May 21). Genome-wide screens for sensitivity to ionizing radiation identify the fission yeast nonhomologous end joining factor Xrc4.

Sastre-Moreno G, et al. (2014 Sep). ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%