FOG00225
EOG8QNKHF
EOG8T1G5W

sce:DPB4

Genes: 30

Protein description
DNA polymerase


SGD Description
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization


PomBase Description
DNA polymerase epsilon subunit Dpb4


AspGD Description
Has domain(s) with predicted protein heterodimerization activity, sequence-specific DNA binding activity and intracellular localization


References

Ohya T, et al. (2000 Oct 15). Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae.

Goldmark JP, et al. (2000 Oct 27). The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p.

Gelbart ME, et al. (2001 Mar). Interactions of Isw2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templates.

Fazzio TG, et al. (2001 Oct). Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression.

Shimizu K, et al. (2002 Oct 4). Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae.

Chilkova O, et al. (2003 Apr 18). The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae.

Spiga MG, et al. (2004). Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

McConnell AD, et al. (2004 Apr). Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo.

Iida T, et al. (2004 Jan). Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae.

Pai CC, et al. (2009 Feb). GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%