FOG19505
EOG808KSS

sce:PPM1

Genes: 33

SGD Description
Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth


PomBase Description
leucine carboxyl methyltransferase, involved in regulation of autophagy Ppm1 (predicted)


AspGD Description
Ortholog(s) have mitochondrion localization


References

Wu J, et al. (2000 Nov 1). Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo.

Kalhor HR, et al. (2001 Nov 15). Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast.

Leulliot N, et al. (2004 Feb 27). Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%