FOG19370
EOG80P2R7

sce:TIM54

Genes: 32

SGD Description
Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane


PomBase Description
TIM22 inner membrane protein import complex subunit Tim54 (predicted)


AspGD Description
Ortholog(s) have protein channel activity, role in protein import into mitochondrial inner membrane and mitochondrial inner membrane protein insertion complex localization


References

Daly S, et al. (1994 Sep 15). Sequence of a dihydrofolate reductase-encoding gene from Candida albicans.

Kerscher O, et al. (1997 Dec 29). The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane.

Kurz M, et al. (1999 Jul). Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway.

Koehler CM, et al. (2000 Feb). Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane.

Kerscher O, et al. (2000 Jan). Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane.

Kovermann P, et al. (2002 Feb). Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel.

Rehling P, et al. (2003 Mar 14). Protein insertion into the mitochondrial inner membrane by a twin-pore translocase.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 27 genes with posterior transmembrane prediction > 50%