FOG19369
EOG80P2RC

sce:UNG1

Genes: 33

SGD Description
Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus


PomBase Description
uracil DNA N-glycosylase Ung1


AspGD Description
Ortholog(s) have uracil DNA N-glycosylase activity, role in DNA repair and mitochondrion, nucleus localization


References

Crosby B, et al. (1981 Nov 11). Purification and characterization of a uracil-DNA glycosylase from the yeast. Saccharomyces cerevisiae.

Percival KJ, et al. (1989 Feb 15). Molecular cloning and primary structure of the uracil-DNA-glycosylase gene from Saccharomyces cerevisiae.

Impellizzeri KJ, et al. (1991 Nov). The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair.

Chatterjee A, et al. (2001 Dec 15). Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype.

Elder RT, et al. (2003 Jul 4). A fission yeast homologue of the human uracil-DNA-glycosylase and their roles in causing DNA damage after overexpression.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Lucaccioni A, et al. (2007 Nov). High rate of starvation-associated mutagenesis in Ung(-) yeast caused by the overproduction of human activation-induced deaminase.

Zamir L, et al. (2012 Feb 14). Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%