FOG18977
EOG81RNCC

sce:HAT1

Genes: 31

SGD Description
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair


PomBase Description
histone acetyltransferase Hat1


AspGD Description
Ortholog(s) have H4 histone acetyltransferase activity, chromatin binding, histone acetyltransferase activity, histone binding activity


References

Kleff S, et al. (1995 Oct 20). Identification of a gene encoding a yeast histone H4 acetyltransferase.

Parthun MR, et al. (1996 Oct 4). The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism.

Dutnall RN, et al. (1998 Aug 21). Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.

Ruiz-García AB, et al. (1998 May 15). HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4.

Kelly TJ, et al. (2000 Oct). Type B histone acetyltransferase Hat1p participates in telomeric silencing.

Qin S, et al. (2002 Dec). Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair.

Poveda A, et al. (2004 Apr 16). Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus.

Ai X, et al. (2004 Apr 23). The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly.

Benson LJ, et al. (2007 Jan 12). Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Takahashi H, et al. (2011 Mar 4). Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.

Tong K, et al. (2012 Sep). Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

Subramanian L, et al. (2014 Apr 30). Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Hayashi T, et al. (2014 Jul). Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.

Li Y, et al. (2014 Jun 1). Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.

Pai CC, et al. (2014 Jun 9). A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%