FOG17939
EOG84B8JG

sce:SRV2

Genes: 33

SGD Description
CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus, in physically and genetically separate activity, binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins


PomBase Description
adenylyl cyclase-associated protein Cap1


AspGD Description
Has domain(s) with predicted actin binding activity and role in cell morphogenesis, cytoskeleton organization


References

Fedor-Chaiken M, et al. (1990 Apr 20). SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

Field J, et al. (1990 Apr 20). Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein.

Kawamukai M, et al. (1992 Feb). Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe.

Freeman NL, et al. (1996 Feb). A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Dodatko T, et al. (2004 Aug 24). Crystal structure of the actin binding domain of the cyclase-associated protein.

Lafon A, et al. (2006 Jul). G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Yamamoto T, et al. (2015 Dec). Identification and characterization of Csh3 as an SH3 protein that interacts with fission yeast Cap1.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%