FOG17755
EOG84TMQ0

sce:UBP3

Genes: 32

SGD Description
Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress; role in ribophagy


PomBase Description
ubiquitin C-terminal hydrolase Ubp3


AspGD Description
Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination and cytosol, nucleus localization


References

Baker RT, et al. (1992 Nov 15). Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family.

Moazed D, et al. (1996 Aug 23). A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae.

Cohen M, et al. (2003 Jul). Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23.

Li K, et al. (2007 Sep 7). Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%