FOG17754
EOG84TMQ1

sce:CCR4

Genes: 33

SGD Description
Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening


PomBase Description
CCR4-Not complex subunit Ccr4 (predicted)


AspGD Description
Ortholog(s) have role in deadenylation-dependent decapping of nuclear-transcribed mRNA and cytosol, nucleus localization


References

Malvar T, et al. (1992 Dec). The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression.

Barton AB, et al. (1994 Apr). Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region.

Liu HY, et al. (1998 Feb 16). The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.

Bai Y, et al. (1999 Oct). The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.

Chen J, et al. (2001 Dec 7). Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.

Tucker M, et al. (2001 Feb 9). The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.

Chen J, et al. (2002 Mar 15). CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.

Tucker M, et al. (2002 Mar 15). Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%