FOG17590
EOG8573RW

sce:KIN3

Genes: 32

SGD Description
Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol


PomBase Description
serine/threonine protein kinase, NIMA related Fin1


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity and role in G2/M transition of mitotic cell cycle, ascospore formation, chromosome segregation, histone H3-S10 phosphorylation, positive regulation of mitotic nuclear division


References

Morris NR, et al. (1975 Dec). Mitotic mutants of Aspergillus nidulans.

Oakley BR, et al. (1983 Apr). A mutation in Aspergillus nidulans that blocks the transition from interphase to prophase.

Osmani SA, et al. (1987 Jun). Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans.

Osmani SA, et al. (1988 Apr 22). Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase.

Osmani SA, et al. (1988 Jan 29). Spindle formation and chromatin condensation in cells blocked at interphase by mutation of a negative cell cycle control gene.

Morris NR, et al. (1989 Jun). The genetic analysis of mitosis in Aspergillus nidulans.

Jones DG, et al. (1990 May 31). Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing.

Osmani AH, et al. (1991). Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: evidence for two pathways of mitotic regulation.

Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.

Osmani AH, et al. (1991 Oct 18). Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans.

Murray AW, et al. (1991 Oct 24). Cell Biology. Never-in-mitosis in mitosis.

Osmani AH, et al. (1991 Sep). Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.

Morris NR, et al. (1992). Mitotic regulation in Aspergillus nidulans.

Barton AB, et al. (1992 Aug 1). Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases.

Schweitzer B, et al. (1992 Jul). NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA.

Doonan JH, et al. (1992 Nov). Cell division in Aspergillus.

Letwin K, et al. (1992 Oct). A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.

Lu KP, et al. (1993 Apr 25). Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans.

Lu KP, et al. (1993 May). Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.

Schultz SJ, et al. (1993 Oct). Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

Clark MW, et al. (1994 Apr). Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region.

Schultz SJ, et al. (1994 Jun). Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.

Lu KP, et al. (1994 Mar 4). Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase.

Lu KP, et al. (1994 May 1). Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.

O'Connell MJ, et al. (1994 Oct 17). Premature chromatin condensation upon accumulation of NIMA.

Lu KP, et al. (1995). The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.

Pu RT, et al. (1995 Jul 28). Isolation of a functional homolog of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans and functional analysis of conserved residues.

Pu RT, et al. (1995 Mar 1). Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit.

Ye XS, et al. (1995 Mar 1). The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

Fry AM, et al. (1995 May 26). Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans.

Lu KP, et al. (1995 May 5). Evidence for a NIMA-like mitotic pathway in vertebrate cells.

James SW, et al. (1995 Nov). The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.

Fry AM, et al. (1995 Oct 1). Cell cycle. The NIMA kinase joins forces with Cdc2.

Lu KP, et al. (1996 Apr 11). A human peptidyl-prolyl isomerase essential for regulation of mitosis.

Wolkow TD, et al. (1996 Aug). Cytokinesis in Aspergillus nidulans is controlled by cell size, nuclear positioning and mitosis.

Osmani SA, et al. (1996 Aug 1). Cell cycle regulation in Aspergillus by two protein kinases.

Ye XS, et al. (1996 Jul 15). Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.

Ye XS, et al. (1997). Characterization of NIMA protein kinase in Aspergillus nidulans.

Ye XS, et al. (1997). Regulation of p34cdc2/cyclinB H1 and NIMA kinases during the G2/M transition and checkpoint responses in Aspergillus nidulans.

Tanaka K, et al. (1997 Dec 15). The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis.

Dayton JS, et al. (1997 Feb 7). Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle.

Ye XS, et al. (1997 Jan 2). The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.

Krien MJ, et al. (1998 Apr). A NIMA homologue promotes chromatin condensation in fission yeast.

Arama E, et al. (1998 Apr 9). Murine NIMA-related kinases are expressed in patterns suggesting distinct functions in gametogenesis and a role in the nervous system.

Wang S, et al. (1998 Aug 15). Molecular cloning and cell-cycle-dependent expression of a novel NIMA (never-in-mitosis in Aspergillus nidulans)-related protein kinase (TpNrk) in Tetrahymena cells.

Fry AM, et al. (1998 Jan 15). A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

Fry AM, et al. (1998 Jun 29). C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.

Wu L, et al. (1998 Jun 29). A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans.

Lies CM, et al. (1998 May). BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function.

Ye XS, et al. (1998 Nov). Regulation of the anaphase-promoting complex/cyclosome by bimAAPC3 and proteolysis of NIMA.

Nakashima S, et al. (1999). Stress-responsive gene expression in Tetrahymena.

Sun S, et al. (1999 Apr). Ectopic expression of the Aspergillus nidulans mitotic inducer, nimA kinase, in megakaryocytes: effect on polyploidization.

Ye XS, et al. (1999 Dec 15). Interaction between developmental and cell cycle regulators is required for morphogenesis in Aspergillus nidulans.

Fry AM, et al. (1999 Jun 4). Activity of the human centrosomal kinase, Nek2, depends on an unusual leucine zipper dimerization motif.

De Souza CP, et al. (1999 Nov). Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans.

Hayashi K, et al. (1999 Oct 22). Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans.

Hofmann AF, et al. (2000 Apr). The Aspergillus nidulans uvsB gene encodes an ATM-related kinase required for multiple facets of the DNA damage response.

De Souza CP, et al. (2000 Aug 4). Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans.

Fujioka T, et al. (2000 Dec 29). Nek2 expression and localization in porcine oocyte during maturation.

Wolkow TD, et al. (2000 Jan). Hypomorphic bimA(APC3) alleles cause errors in chromosome metabolism that activate the DNA damage checkpoint blocking cytokinesis in Aspergillus nidulans.

Fry AM, et al. (2000 Jun). The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis.

Kandli M, et al. (2000 Sep 1). Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA.

Kimura M, et al. (2001). Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3).

Bruschi GC, et al. (2001 Apr). Sensitivity to camptothecin in Aspergillus nidulans identifies a novel gene, scaA+, related to the cellular DNA damage response.

Ha Kim Y, et al. (2002 Jan 18). Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle.

Grallert A, et al. (2002 Jun 17). Schizosaccharomyces pombe NIMA-related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB.

Fry AM, et al. (2002 Sep 9). The Nek2 protein kinase: a novel regulator of centrosome structure.

Osmani AH, et al. (2003 Aug). TINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest.

Yin MJ, et al. (2003 Dec 26). The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis.

Surpili MJ, et al. (2003 Dec 30). Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.

Semighini CP, et al. (2003 Jun). Different roles of the Mre11 complex in the DNA damage response in Aspergillus nidulans.

O'Connell MJ, et al. (2003 May). Never say never. The NIMA-related protein kinases in mitotic control.

De Souza CP, et al. (2003 Nov). The SONB(NUP98) nucleoporin interacts with the NIMA kinase in Aspergillus nidulans.

Osmani SA, et al. (2004 Apr). The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans.

Davies JR, et al. (2004 Dec). Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.

Pitt CW, et al. (2004 Jan 15). The pot1+ homologue in Aspergillus nidulans is required for ordering mitotic events.

Joseph JD, et al. (2004 Jul 30). PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.

Lou Y, et al. (2004 May 7). NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

De Souza CP, et al. (2004 Nov 23). Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans.

Fagundes MR, et al. (2005 Jul). Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damage.

Kim S, et al. (2007 Aug 17). NEK7 is a centrosomal kinase critical for microtubule nucleation.

O'regan L, et al. (2007 Aug 29). Mitotic regulation by NIMA-related kinases.

Lee EJ, et al. (2007 Jul 6). Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins.

Kato Y, et al. (2007 Sep). PinA from Aspergillus nidulans binds to pS/pT-P motifs using the same Loop I and XP groove as mammalian Pin1.

Ukil L, et al. (2008 Dec). Copy number suppressors of the Aspergillus nidulans nimA1 mitotic kinase display distinctive and highly dynamic cell cycle-regulated locations.

Liu HL, et al. (2009 Jan). The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex.

Moura DJ, et al. (2010 Jun 1). Kin3 protein, a NIMA-related kinase of Saccharomyces cerevisiae, is involved in DNA adduct damage response.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Govindaraghavan M, et al. (2014 Aug). The Set1/COMPASS histone H3 methyltransferase helps regulate mitosis with the CDK1 and NIMA mitotic kinases in Aspergillus nidulans.

Govindaraghavan M, et al. (2014 Jan). The NIMA kinase is required to execute stage-specific mitotic functions after initiation of mitosis.

Larson JR, et al. (2014 Jan). Insights into dynamic mitotic chromatin organization through the NIMA kinase suppressor SonC, a chromatin-associated protein involved in the DNA damage response.

Shen KF, et al. (2014 Mar). Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase.

Meirelles GV, et al. (2014 May 26). Stop Ne(c)king around: How interactomics contributes to functionally characterize Nek family kinases.

Basei FL, et al. (2015). New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

Markossian S, et al. (2015 Feb 15). Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%