FOG17461
EOG85MKMT

sce:HSC82;HSP82

Genes: 35

SGD Description
Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication|Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication


PomBase Description
Hsp90 chaperone


AspGD Description
Hsp90 chaperone


References

Farrelly FW, et al. (1984 May 10). Complete sequence of the heat shock-inducible HSP90 gene of Saccharomyces cerevisiae.

Borkovich KA, et al. (1989 Sep). hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

Hoffman CS, et al. (1990 Apr). Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.

Hoffman CS, et al. (1991 Apr). Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Bohen SP, et al. (1993 Dec 1). Isolation of Hsp90 mutants by screening for decreased steroid receptor function.

Nadeau K, et al. (1993 Jan 15). Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

Aligue R, et al. (1994 Dec 15). A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.

Shiozaki K, et al. (1994 Jun). Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe.

Chang HC, et al. (1994 Oct 7). Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae.

Nocero M, et al. (1994 Sep). Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Nathan DF, et al. (1995 Jul). Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase.

Jin M, et al. (1995 Jun). sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.

Boucherie H, et al. (1995 Jun 15). Two-dimensional protein map of Saccharomyces cerevisiae: construction of a gene-protein index.

Swoboda RK, et al. (1995 Nov). Structure and regulation of the HSP90 gene from the pathogenic fungus Candida albicans.

Duina AA, et al. (1996 Dec 6). A cyclophilin function in Hsp90-dependent signal transduction.

Swoboda RK, et al. (1996 Feb). Structure and regulation of the Hsp90 gene from the pathogenic fungus Candida albicans.

Santo PD, et al. (1996 Jul). The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

Zarzov P, et al. (1997 Aug). A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication.

Prodromou C, et al. (1997 Jul 11). Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

Prodromou C, et al. (1997 Jun). A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.

Dolinski KJ, et al. (1998 Dec). CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.

Fang Y, et al. (1998 Jul). SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins.

Zhang L, et al. (1998 Jul). Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1.

Obermann WM, et al. (1998 Nov 16). In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.

Donzé O, et al. (1999 Dec). Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected].

Roe SM, et al. (1999 Jan 28). Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Muñoz MJ, et al. (1999 Mar). Genetic interactions between Hsp90 and the Cdc2 mitotic machinery in the fission yeast Schizosaccharomyces pombe.

Liu XD, et al. (1999 Sep 17). The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone.

Scheufler C, et al. (2000 Apr 14). Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine.

Prodromou C, et al. (2000 Aug 15). The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains.

Imai J, et al. (2000 Dec). Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin.

Abbas-Terki T, et al. (2000 Feb 4). The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest.

Goes FS, et al. (2001 Apr). Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

Ki SW, et al. (2001 Nov). Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast.

Panaretou B, et al. (2002 Dec). Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.

Saitoh S, et al. (2002 May 31). Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Matsumoto S, et al. (2002 Sep 20). Interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 molecular chaperone.

Meyer P, et al. (2003 Mar). Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Meyer P, et al. (2004 Feb 11). Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

Roe SM, et al. (2004 Jan 9). The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37).

Meyer P, et al. (2004 Mar 24). Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.

Bansal PK, et al. (2004 Sep). Sgt1 associates with Hsp90: an initial step of assembly of the core kinetochore complex.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Turnbull EL, et al. (2005 Aug). Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Mishra M, et al. (2005 Mar). Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.

Ali MM, et al. (2006 Apr 20). Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.

Richter K, et al. (2006 Apr 21). Intrinsic inhibition of the Hsp90 ATPase activity.

Proisy N, et al. (2006 Nov). Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

Nicolas E, et al. (2006 Nov 24). Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Breakspear A, et al. (2007 Sep). Aspergillus nidulans conidiation genes dewA, fluG, and stuA are differentially regulated in early vegetative growth.

Alaamery MA, et al. (2008 Apr). Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Calvert ME, et al. (2008 Feb). Phosphorylation by casein kinase 2 regulates Nap1 localization and function.

Araújo-Bazán L, et al. (2008 Mar). NapA and NapB are the Aspergillus nidulans Nap/SET family members and NapB is a nuclear protein specifically interacting with importin alpha.

Hawkins TA, et al. (2008 Mar). The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Martin CJ, et al. (2008 May 8). Molecular characterization of macbecin as an Hsp90 inhibitor.

Prodromou C, et al. (2009 Apr 17). Structural basis of the radicicol resistance displayed by a fungal hsp90.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Retzlaff M, et al. (2009 Oct). Hsp90 is regulated by a switch point in the C-terminal domain.

Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

Cho SJ, et al. (2010 Jun). Possible Roles of LAMMER Kinase Lkh1 in Fission Yeast by Comparative Proteome Analysis.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Zhu XJ, et al. (2010 Sep 24). The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Freitas JS, et al. (2011 Sep). Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulans.

Santino A, et al. (2012 Aug). Hsp90 interaction with Cdc2 and Plo1 kinases contributes to actomyosin ring condensation in fission yeast.

Flom GA, et al. (2012 Jun). Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae.

Vjestica A, et al. (2013). Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.

Wang CY, et al. (2013 Mar). Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.

Ishida M, et al. (2013 Oct). Biochemical characterization and cooperation with co-chaperones of heat shock protein 90 from Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Jaimes-Arroyo R, et al. (2015 May). The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%