FOG17454
EOG85MKNR

sce:ABD1

Genes: 32

SGD Description
Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia


PomBase Description
P-TEFb-cap methyltransferase Pcm1


AspGD Description
Ortholog(s) have mRNA (guanine-N7-)-methyltransferase activity and role in 7-methylguanosine mRNA capping, RNA (guanine-N7)-methylation, cellular response to drug, mRNA methylation


References

Mao X, et al. (1995 Aug). Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene.

Mao X, et al. (1996 Feb). Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth.

Wang SP, et al. (1997 Jun 6). Structure-function analysis of the mRNA cap methyltransferase of Saccharomyces cerevisiae.

Saha N, et al. (1999 Jun 4). Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes.

Schroeder SC, et al. (2000 Oct 1). Dynamic association of capping enzymes with transcribing RNA polymerase II.

Bujnicki JM, et al. (2001). mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships.

Pei Y, et al. (2006 Feb). Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.

Hausmann S, et al. (2007). Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe.

Viladevall L, et al. (2009 Mar 27). TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

St Amour CV, et al. (2012 Jul). Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%