FOG17072
EOG86M92K

sce:SWD2

Genes: 34

SGD Description
Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination


PomBase Description
Set1C complex subunit Swd2.1|mRNA cleavage and polyadenylation specificity factor complex subunit, WD repeat protein Swd22


AspGD Description
Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity


References

Roguev A, et al. (2001 Dec 17). The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.

Miller T, et al. (2001 Nov 6). COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.

Krogan NJ, et al. (2002 Mar 29). COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.

Nedea E, et al. (2003 Aug 29). Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.

Kanoh J, et al. (2003 Feb 28). The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway.

Roguev A, et al. (2003 Mar 7). High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts.

Cheng H, et al. (2004 Apr). The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3.

Roguev A, et al. (2004 Feb). A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Fontebasso Y, et al. (2013 Dec). The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Vanoosthuyse V, et al. (2014 Jun). CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Legros P, et al. (2014 Nov). RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%