FOG17070
EOG86M92V

sce:NTG1;NTG2

Genes: 33

SGD Description
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication|DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication


PomBase Description
DNA endonuclease III


AspGD Description
Ortholog(s) have 5-formyluracil DNA N-glycosylase activity, 5-hydroxymethyluracil DNA N-glycosylase activity, 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity, role in base-excision repair, AP site formation and nucleus localization


References

Barton AB, et al. (1994 Apr). Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region.

Nash HM, et al. (1996 Aug 1). Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily.

Eide L, et al. (1996 Oct 1). Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli.

Augeri L, et al. (1997 Jan 28). Purification, characterization, gene cloning, and expression of Saccharomyces cerevisiae redoxyendonuclease, a homolog of Escherichia coli endonuclease III.

You HJ, et al. (1998 Apr 28). Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III.

Sentürker S, et al. (1998 Dec 1). Substrate specificities of the ntg1 and ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical.

Bruner SD, et al. (1998 Mar 26). Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway.

You HJ, et al. (1999 Aug 31). Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria.

Alseth I, et al. (1999 May). The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast.

Kim JE, et al. (2001 Aug 3). Ntg2 of Saccharomyces cerevisiae repairs the oxidation products of 8-hydroxyguanine.

Gellon L, et al. (2002 Aug 16). Ntg2p, a Saccharomyces cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage, interacts with the DNA mismatch repair protein Mlh1p. Identification of a Mlh1p binding motif.

Meadows KL, et al. (2003 Oct 1). Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function.

Hanna M, et al. (2004 Jan 5). Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.

Melo RG, et al. (2004 Sep). Role of OGG1 and NTG2 in the repair of oxidative DNA damage and mutagenesis induced by hydrogen peroxide in Saccharomyces cerevisiae: relationships with transition metals iron and copper.

Doudican NA, et al. (2005 Jun). Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae.

Phadnis N, et al. (2006 Jul 13). Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNA.

Griffiths LM, et al. (2009 Feb). Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress.

Hori A, et al. (2009 Feb). Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication.

Gasparutto D, et al. (2009 Jan 1). Excision of the oxidatively formed 5-hydroxyhydantoin and 5-hydroxy-5-methylhydantoin pyrimidine lesions by Escherichia coli and Saccharomyces cerevisiae DNA N-glycosylases.

Swartzlander DB, et al. (2010 Jul). Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%