FOG16865
EOG876HF5

sce:AXL2

Genes: 33

SGD Description
Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate


AspGD Description
Ortholog(s) have role in cell morphogenesis, negative regulation of sexual sporulation resulting in formation of a cellular spore, phialide development, sexual sporulation resulting in formation of a cellular spore


References

Matsui Y, et al. (1992 Dec). Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1.

Torpey LE, et al. (1994 Nov). Cloning and sequence of REV7, a gene whose function is required for DNA damage-induced mutagenesis in Saccharomyces cerevisiae.

Roemer T, et al. (1996 Apr 1). Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein.

Halme A, et al. (1996 May 1). Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor.

Powers J, et al. (1998 Sep 7). Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product.

Sanders SL, et al. (1999 Jun 14). O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells.

Lord M, et al. (2000 Dec 25). Cell cycle programs of gene expression control morphogenetic protein localization.

Freedman T, et al. (2000 Nov). Mutational and hyperexpression-induced disruption of bipolar budding in yeast.

Kang PJ, et al. (2001 May 18). A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity.

Cullen PJ, et al. (2002 Sep). The roles of bud-site-selection proteins during haploid invasive growth in yeast.

Sundin BA, et al. (2004 Jul 15). Localization of proteins that are coordinately expressed with Cln2 during the cell cycle.

Gao XD, et al. (2007 Jul). Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Si H, et al. (2012 Jul). Morphogenetic and developmental functions of the Aspergillus nidulans homologues of the yeast bud site selection proteins Bud4 and Axl2.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%