FOG16328
EOG88PK16

sce:RQC2

Genes: 32

SGD Description
Component of RQC, which mediates nascent chain degradation; RQC (ribosome quality control complex) is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p


PomBase Description
microtubule regulator Mtr1


AspGD Description
Ortholog(s) have cytosol localization


References

Fleischer TC, et al. (2006 May 15). Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes.

Alamgir M, et al. (2010 Aug 6). Chemical-genetic profile analysis of five inhibitory compounds in yeast.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Brandman O, et al. (2012 Nov 21). A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Defenouillère Q, et al. (2013 Mar 26). Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carlier-Grynkorn F, et al. (2014 Jun 13). Fission yeast mtr1p regulates interphase microtubule cortical dwell-time.

Lyumkis D, et al. (2014 Nov 11). Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex.

Shen PS, et al. (2015 Jan 2). Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 10 genes with posterior transmembrane prediction > 50%