FOG16327
EOG88PK19

sce:HSL7

Genes: 35

SGD Description
Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress


PomBase Description
type II protein arginine N-methyltransferase Skb1


AspGD Description
Ortholog(s) have histone-arginine N-methyltransferase activity


References

Ma XJ, et al. (1996 Jun 1). A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae.

Fujita A, et al. (1999 Jul 20). Hsl7p, a negative regulator of Ste20p protein kinase in the Saccharomyces cerevisiae filamentous growth-signaling pathway.

McMillan JN, et al. (1999 Oct). The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p.

Shulewitz MJ, et al. (1999 Oct). Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae.

Lee JH, et al. (2000 Jul 21). Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase.

Trojer P, et al. (2004 Aug 24). Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity.

Miranda TB, et al. (2006 May 1). Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Sayegh J, et al. (2008 Aug 8). Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast.

Bauer I, et al. (2010 Jun). Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%